Variation of radon retention parameters for radium-burdened dog skeletons as a function of exposure age and dosage level

Journal Article · Wed Feb 01 04:00:00 EST 1978 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3574820· OSTI ID:7208128

Parks, N J; Pool, R R; Williams, J R

Radium-226 was administered to 36 beagles at various levels in eight semimonthly injections at ages 60 to 160, 120 to 220, or 435 to 535 days. Approximately 400 individual radon retention values were obtained from ..gamma..-ray spectra taken at intervals over the life span of the animals. Radon retention was fitted by regression analysis to a power function of the form At/sup b/ (t = time after injection midpoint). Mean values and associated standard errors of the parameters anti A (SE) and anti b (SE), for animals of both sexes given 10 ..mu..Ci/kg body weight at injection midpoint ages of 110, 170, and 485 days were (3.11 (0.15 SE); 0.293 (0.006 SE)), (5.31 (0.38 SE); 0.214 (0.006 SE)), and (6.08 (0.21 SE); 0.200 (0.007 SE)), respectively. The smaller coefficients, A (t = 1-day intercept), and larger exponents, b (rate parameter), found for earlier ages at injection are attributed to age-dependent differences in the mineral density of bone and the intrabone radium distribution pattern. The mean values of the parameters for animals receiving total dosages < or = 1.12-..mu..Ci/kg body weight at a midpoint age of 485 days were (7.88 (0.31 SE); 0.153 (0.005 SE)). The differences in retention function parameters between the higher and lower /sup 226/Ra dosage levels are interpreted in terms of radiation damage to bone which alters the degree of mineralization in regions of radium deposition.

• Research Organization: Univ. of California, Davis
• OSTI ID: 7208128
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 73:2; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560162 -- Radionuclide Effects
Kinetics
&amp; Toxicology-- Animals
Plants
Microorganisms
&amp; Cells
560172* -- Radiation Effects-- Nuclide Kinetics &amp; Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
ALKALINE EARTH ISOTOPES
ALPHA DECAY RADIOISOTOPES
ANIMALS
BEAGLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DAYS LIVING RADIOISOTOPES
DOGS
DOSE-RESPONSE RELATIONSHIPS
EVEN-EVEN NUCLEI
HEAVY NUCLEI
INJECTION
INTAKE
ISOTOPES
MAMMALS
NUCLEI
ORGANS
RADIATION EFFECTS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIUM 226
RADIUM ISOTOPES
RADON 222
RADON ISOTOPES
RETENTION
RETENTION FUNCTIONS
SKELETON
VERTEBRATES
YEARS LIVING RADIOISOTOPES