Retention and distribution of $sup 226$Ra in beagles: a comparison between multiple and single injections
Skeletal uptake, retention, and distribution of $sup 226$Ra were studied in 330 beagles administered eight semi-monthly i.v. injections of radium starting at 2, 4, and 14 months of age. Skeletal uptake, the ratio of body burden at 35 days post-injection (A$sub 35$) to the total injected dose (A$sub 0$) was 71.7 percent, 78.1 percent and 38.5 percent, for a dose of 10 $mu$Ci/kg body weight administered starting at 2, 4, and 14 months of age, respectively. Skeletal retention of radium 350 days post-injection (A$sub 350$/A$sub 0$) was 67.2 percent, 73.3 percent, and 27.7 percent. Comparison of $sup 226$Ra retention from single and multiple injections of radium shows that at dose level 6.064 $mu$Ci/kg the retention functions for periods 35 days after injection are identical; for dose level 10 $mu$Ci/kg, a larger retention is observed for multiple-injection groups. Comparison of $sup 226$Ra retention in man with that in beagles shows that within a period between 35 days and 6000 days post-- injection, the body burden in dog decreases by about 6 times in contrast with 43 times in man. Regional distribution of $sup 226$Ra in bone matrix at proximal, midshaft, and distal humeri from 21 beagles shows the highest concentration of the radionuclide at proximal regions. Radium distribution on autoradiograms shows a uniform distribution in 4-month-old beagles in contrast to ''hot spots'' superimposed on a diffuse background for the 14-month age group. Radium in the latter group is located mostly on periosteum and endosteum surfaces. (auth)
- Research Organization:
- California Univ., Davis (USA). School of Veterinary Medicine
- NSA Number:
- NSA-33-023596
- OSTI ID:
- 4061312
- Report Number(s):
- UCD--472-122
- Country of Publication:
- United States
- Language:
- English
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*RADIUM 226-- TISSUE DISTRIBUTION
*TISSUES-- RADIONUCLIDE KINETICS
560172* --Biomedical Sciences
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N48720* --Life Sciences--Nuclide Kinetics & Toxicology-- Animals
RADIATION DOSES