Dose rates, dose and age effects of $sup 90$Sr--$sup 90$Y and $sup 226$Ra body burden on radiation-induced skeletal injury, primary bone sarcomas and mortality in beagles

Technical Report · Sun Jun 01 04:00:00 EDT 1975

OSTI ID:4052431

Momeni, M H; Williams, J R; Jow, N; Rosenblatt, L S; Goldman, M

Radiation-induced skeletal injury (E), primary bone sarcomas (PBS) and lifespan shortening ($delta$) were studied in beagles fed $sup 90$SrCl$sub 2$ for 1.5 years or administered $sup 226$Ra Cl (iv) over four months starting at 2, 4, or 14 months of age. Lifespan shortening was compared with that caused by a single injection of $sup 90$Sr or $sup 226$Ra or by inhalation of $sup 90$SrCl$sub 2$. Skeletal changes were assessed by a radiographic x-ray score. Bone changes in $sup 90$Sr or $sup 226$Ra labeled humeri were compared with skeletal scores. Skeletal changes classified included endosteal and/or periosteal cortical sclerosis and thickening (ECST, POCST), fractures, osteolytic lesions, and trabecular coarsening. ECST incidence was 100 percent in at least one site in dogs receiving greater than 9.3 $mu$Ci $sup 226$Ra and POCST incidence was 100 percent only at greater than or equal to 83.6 $mu$Ci $sup 226$Ra. At 0.53 $mu$Ci $sup 226$Ra, ECST and POCST incidence were both 5 percent. Fractures were observed at 14 $mu$Ci $sup 226$Ra and were 50 percent and 100 percent at 28.1 $mu$Ci $sup 226$Ra and 83.6 $mu$Ci, respectively. (auth)

• Research Organization: California Univ., Davis (USA). School of Veterinary Medicine
• NSA Number: NSA-33-023595
• OSTI ID: 4052431
• Report Number(s): UCD--472-122
• Country of Publication: United States
• Language: English

Related Subjects

*BONE FRACTURES-- RADIOINDUCTION
*LIFE SPAN-- BIOLOGICAL RADIATION EFFECTS
*OSTEOSARCOMAS-- RADIOINDUCTION
*SKELETON-- RADIATION INJURIES
560172* --Biomedical Sciences
Applied Studies--Radiation Effects--Nuclide Kinetics & Toxicology--Animals
AGE DEPENDENCE
BEAGLES
DOSE RATES
MORTALITY
N48620 --Life Sciences--Radionuclide Effects (Internal Source)--Animals
N48720* --Life Sciences--Nuclide Kinetics & Toxicology-- Animals
RADIUM 226
STRONTIUM 90
YTTRIUM 90