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Lifetime studies of /sup 226/Ra and /sup 90/Sr toxicity in beagles. A status report

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3575467· OSTI ID:6459929
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Beagles at the University of California at Davis injected with /sup 226/Ra of fed /sup 90/Sr have been under lifetime study for over 18 years. This report summarizes the dose-response observations to June 30, 1978. Bone marrow dyscrasias were more numerous than bone cancers from /sup 90/Sr at dose rates to bone of about 2 to 20 rad/day, while bone cancers have been the dominating effect of /sup 226/Ra at dose rates of from 0.5 to about 20 rad/day. No radiogenic effects are yet apparent for skeletal doses below 0.5 rad/day. Results to date indicate that although bone cancer continues to be the important endpoint for /sup 226/Ra, other cancer types appear to be more important for /sup 90/Sr (such as soft-tissue cancers adjacent to bone), particularly at late times from lower skeletal dose rates.

Research Organization:
Univ. of California, Davis
OSTI ID:
6459929
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 86:3; ISSN RAREA
Country of Publication:
United States
Language:
English

Similar Records

Retention and skeletal dosimetry of injected /sup 226/Ra, /sup 228/Ra, and /sup 90/Sr in beagles
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THE EFFECTS OF CONTINUAL Sr$sup 90$ INGESTION DURING THE GROWTH PERIOD OF THE BEAGLE AND ITS RELATION TO Ra$sup 226$ TOXICITY. Annual Progress Report No. 6
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Related Subjects

560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH ISOTOPES
ALPHA DECAY RADIOISOTOPES
ANIMAL TISSUES
ANIMALS
BEAGLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE MARROW
BONE SEEKERS
DELAYED RADIATION EFFECTS
DISEASES
DOGS
DOSE-RESPONSE RELATIONSHIPS
EVEN-EVEN NUCLEI
HEAVY NUCLEI
HEMATOPOIETIC SYSTEM
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
NECROSIS
NEOPLASMS
NUCLEI
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIOINDUCTION
RADIOISOTOPES
RADIUM 226
RADIUM ISOTOPES
SKELETON
STRONTIUM 90
STRONTIUM ISOTOPES
TISSUES
TOXICITY
VERTEBRATES
YEARS LIVING RADIOISOTOPES