Toxicity of $sup 90$Sr--$sup 90$Y in Chinese hamsters

Journal Article · Fri Mar 01 04:00:00 EDT 1974 · Radiat. Res., v. 57, no. 3, pp. 471-481

OSTI ID:4337841

Brooks, A L; Benjamin, S A; McClellan, R O

Strontium-90 citrate was injected intraperitoneally into Chinese hamsters at activity levels of 0.2, 0.5, 1.0, 2.0, 3.0, and 5.0 mu Ci/g body weight and the animals held for lifespan observation. Additional hamsters injected with sodium citrate served as controls. When compared with controls, a lifespan shortening that increased with increasing /sup 90/Sr levels was observed in all /sup 90/Sr-injected animals. Animals that received 3.0 or 5.0 mu Ci/g died within the first 2 weeks postinjection. Those in the other activity level groups had 50% survival rates at 90 days after 2.0 mu Ci/g, 260 days at 1.0 mu Ci, 700 days at 0.5 mu Ci, 900 days at 0.2 mu Ci, and 1100 days for controls. Three osteosarcomas were found, all in animals injected with 1.0 mu Ci/g, a level of activity known to produce a high incidence of bone tumors in the mouse. The results suggest that the Chinese hamster is more resistant to bone tumor induction than is the mouse. A high incidence of myeloproliferative disorders was found both in older control and /sup 90/Sr-injected animals. (auth)

• Research Organization: Lovelace Foundation for Medical Education and Research, Albuquerque, NM
• NSA Number: NSA-29-027126
• OSTI ID: 4337841
• Journal Information: Radiat. Res., v. 57, no. 3, pp. 471-481, Journal Name: Radiat. Res., v. 57, no. 3, pp. 471-481; ISSN RAREA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

*HAMSTERS-- BIOLOGICAL RADIATION EFFECTS
*OSTEOSARCOMAS-- RADIOINDUCTION
*STRONTIUM 90-- TOXICITY
*YTTRIUM 90-- TOXICITY
BONE MARROW
CITRATES
DOSE-RESPONSE RELATIONSHIPS
INTRAPERITONEAL INJECTION
LIFE SPAN
N48620* --Life Sciences--Radionuclide Effects (Internal Source)--Animals
SURVIVAL TIME RADIOINDUCTION