Vaccination against strontium-90-induced bone tumors

Journal Article · Thu Sep 01 04:00:00 EDT 1983 · JNCI, J. Natl. Cancer Inst.; (United States)

OSTI ID:5427454

Reif, A E; Triest, W E

The thesis was tested that immunization against a murine osteosarcoma virus can reduce the incidence of bone tumors induced by /sup 90/Sr. C57BL/6J female mice (190) were divided into three sets of 2 groups. Each set consisted of a control group and an experimental group treated ip with 1.0 muCi /sup 90/Sr at 66 days of age. The three sets of groups received the following additional treatments: none (controls), 6 injections of Formalin-inactivated FBJ osteosarcoma virus (vaccinated group), or 6 injections of active FBJ virus (active virus controls). Only 1 bone tumor developed in a mouse not treated with /sup 90/Sr in the active virus controls. In /sup 90/Sr-treated mice, vaccination reduced bone tumor deaths during the first 600 days from 9 of 36 in controls to 1 of 33 in vaccinated mice (P less than .01), but bone tumor deaths during the entire life-span, 10 of 36 and 5 of 33, respectively, were not significantly different (P . .07). Thus the vaccination procedure delayed the development of bone tumors. In contrast, injection of active virus into /sup 90/Sr-treated mice increased the lifetime incidence of bone tumors from 10 of 36 in controls to 19 of 32 (P . .01).

• Research Organization: Laboratory of Experimental Cancer Immunotherapy, Boston University School of Medicine, Boston City Hospital, MA
• OSTI ID: 5427454
• Journal Information: JNCI, J. Natl. Cancer Inst.; (United States), Journal Name: JNCI, J. Natl. Cancer Inst.; (United States) Vol. 71:3; ISSN JJIND
• Country of Publication: United States
• Language: English

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560162* -- Radionuclide Effects
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH ISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
DISEASES
EVEN-EVEN NUCLEI
FEMALES
IMMUNITY
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
MICE
MICROORGANISMS
NEOPLASMS
NUCLEI
ONCOGENIC VIRUSES
ORGANS
OSTEOSARCOMAS
PARASITES
RADIOINDUCTION
RADIOISOTOPES
RODENTS
SARCOMAS
SKELETAL DISEASES
SKELETON
STRONTIUM 90
STRONTIUM ISOTOPES
VACCINES
VERTEBRATES
VIRUSES
YEARS LIVING RADIOISOTOPES