SOME LATE EFFECTS OF RADIOSTRONTIUM IN RF MALE MICE

Journal Article · Sun Jul 01 04:00:00 EDT 1962 · J. Nuclear Med.

OSTI ID:4838068

Cosgrove, G E; Upton, A C

Young adult RF male mice were injected intravenously with radioactive strontium as followsn Group l, 0.2 Vc Sr/sup 90/g after splenectomy; Group II, 0.2 mu c Sr/sup 90/g after sham splenectomy; Group III, 0.51 gamma c Sr/sup 89// g; Group IV, 0.04 mu c Sr/sup 90//g; and Group V, uninjected controls. After injection, the mice were observed until death, and effects on the life span and incidence of neoplastic and norneoplastic diseases were studied. A dose of 0.2 mu c Sr/sup 90//g, with or without splenectomy, increased the incidence of thymic lymphosarcoma but did not detectably alter the incidence of myeloid leukemia. Other leukemias and lymphomas were also increased in number and occurred earlier. Two malignant bone tumors were found in 102 animals receiving 0.2 mu c Sr/sup 90//g, and one in 75 animals receiving 0.04 mu c Sr/sup 90//g, while none were noted in controls or in animals receiving 0.51 mu c Sr/sup 89//g. Effects on the life span were variable and of equivocal biological significance. (auth)

• Research Organization: Oak Ridge National Lab., Tenn.
• NSA Number: NSA-16-021953
• OSTI ID: 4838068
• Journal Information: J. Nuclear Med., Journal Name: J. Nuclear Med. Vol. Vol: 3
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BONES
LEUKEMIA
LIFETIME
MICE
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
SEX
SPLEEN
STRONTIUM 90
SURGERY
TUMORS