Relative radiosensitivity of bone tumor induction among beagles as a function of age at injection of {sup 239}Pu or {sup 226}Ra

Journal Article · Fri Jan 01 04:00:00 EST 1999 · Health Physics

DOI:https://doi.org/10.1097/00004032-199901000-00008· OSTI ID:318657

Lloyd, R D; Taylor, G N; Jee, W S.S.; Miller, S C ^[1]

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1. Univ. of Utah, Salt Lake City, UT (United States). Radiobiology Lab.

A comparison was made of the response to induction of skeletal malignancy from exposure of beagles to monomeric {sup 239}Pu or to {sup 226}Ra as juveniles (3 mo of age), young adults (1.5 y of age), or mature adults (5 y of age). This indicated that of these age groups, animals injected as young adults are most sensitive per Gy of average skeletal dose evaluated at 1 y before death. Dogs exposed either as juveniles or as mature adults appeared to be less sensitive. Relative radiosensitivities (RRS) of juvenile and mature beagles ranged between about 0.3 and 0.7 that of dogs injected as young adults. Mean values of RRS for both radionuclides were about 0.5, but RRS values derived from dogs given monomeric {sup 239}Pu appeared to be most reliable and were 0.27 {+-} 0.09 for dogs injected as juveniles and 0.41 {+-} 0.13 for animals exposed as mature adults.

• Sponsoring Organization: USDOE, Washington, DC (United States); National Cancer Inst., Bethesda, MD (United States)
• DOE Contract Number: AC04-76EV01013
• OSTI ID: 318657
• Journal Information: Health Physics, Journal Name: Health Physics Journal Issue: 1 Vol. 76; ISSN HLTPAO; ISSN 0017-9078
• Country of Publication: United States
• Language: English

Related Subjects

56 BIOLOGY AND MEDICINE
APPLIED STUDIES
AGE DEPENDENCE
BEAGLES
NEOPLASMS
PLUTONIUM 239
RADIOINDUCTION
RADIOSENSITIVITY
RADIUM 226
SKELETON