The influence of age at time of exposure to sup 226 Ra or sup 239 Pu on distribution, retention, postinjection survival, and tumor induction in beagle dogs

Journal Article · Fri Mar 01 04:00:00 EST 1991 · Radiation Research; (USA)

DOI:https://doi.org/10.2307/3578106· OSTI ID:5923575

Bruenger, F W; Lloyd, R D; Miller, S C ^[1]

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1. Univ. of Utah, Salt Lake City (USA)

The influence of age at injection of 226Ra or 239Pu on skeletal deposition and local distribution, the pattern of bone tumor formation, and postinjection survival was assessed in parallel short-term studies of mechanisms and lifetime toxicity. Beagles received a single intravenous injection of 226Ra or 239Pu at 3 months (juveniles), 17-19 months (young adults) or 60 months (mature). Data from short-term studies of mechanisms and dosimetry and from one dosage level of each of the toxicity experiments were compared. Skeletal growth and turnover produced differential initial deposition and distribution patterns typical for each age group. At 1 week after injection, skeletal retention of 226Ra or 239Pu was 68 and 68%, respectively, in the juveniles, 32 and 46% in the young adults, and 31 and 43% in the mature dogs. Comparing individual bones in the juveniles, gradients in the concentration of 239Pu were small since all bones were actively growing, but substantial gradients, corresponding to centers of ossification, were present within individual bones. In other age groups, local concentration gradients were less pronounced, but much larger differences were present among the various bones. In the toxicity study all animals injected with either 41 kBq 226Ra/kg or 11 kBq 239Pu/kg have died. The cumulative average skeletal doses to the presumed time of start of tumor growth (1 year before death) were 25 and 4 Gy, respectively, for the juveniles, 22 and 5 Gy for the young adults, and 15 and 4 Gy for the mature dogs. The highest bone tumor incidence was seen in the young adult groups. Differences were observed in location of bone tumors between dogs in the same age group given radium or plutonium and among age groups injected with either radionuclide, some of which could be explained by differences in local dose distributions.

• OSTI ID: 5923575
• Journal Information: Radiation Research; (USA), Journal Name: Radiation Research; (USA) Vol. 125:3; ISSN RAREA; ISSN 0033-7587
• Country of Publication: United States
• Language: English

Related Subjects

560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
AGE DEPENDENCE
ALKALINE EARTH ISOTOPES
ALPHA DECAY RADIOISOTOPES
ANIMALS
BEAGLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARBON 14 DECAY RADIOISOTOPES
DISTRIBUTION
DOGS
DOSES
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
EXPERIMENTAL NEOPLASMS
HEAVY ION DECAY RADIOISOTOPES
HEAVY NUCLEI
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOTOPES
MAMMALS
NUCLEI
ORGANS
PLUTONIUM 239
PLUTONIUM ISOTOPES
RADIATION DOSES
RADIATION EFFECTS
RADIOINDUCTION
RADIOISOTOPES
RADIUM 226
RADIUM ISOTOPES
RETENTION
SKELETON
SURVIVAL CURVES
TISSUE DISTRIBUTION
TOXICITY
VERTEBRATES
YEARS LIVING RADIOISOTOPES