Radiosensitizing effects of misonidazole and SR 2508 on a human melanoma tranplanted in nude mice: influence on repair of potentially lethal damage

Journal Article · Mon Mar 01 04:00:00 EST 1982 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(82)90662-9· OSTI ID:6704245

Guichard, M; Malaise, E P

The radiosensitizing effects of misonidazole and SR 2508 (1 mg/g) were compared on a human melanoma (Na11) containing 85% hypoxic cells transplanted into nude mice. For both drugs, the enhancement ratios (ER) were 1.7 after immediate plating and 2.1 after delayed plating. This difference in ERs is related to a lack of PLD repair in tumors in the presence of the sensitizer. The effect of misonidazole was also investigated in another human melanoma (Be11) containing 40% hypoxic cells. After immediate plating, the Er was similar to that observed with the Na11 tumor (1.7)m but PLD repair was not reduced. A comparative analysis of the influence of misonidazole on the response (survival curve - PLD repair) of Na11 melanoma to different ionizing radiations was attempted.

• OSTI ID: 6704245
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 8:3/4; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTINEOPLASTIC DRUGS
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
DISEASES
DRUGS
EXPERIMENTAL NEOPLASMS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IONIZING RADIATIONS
MAMMALS
MAN
MELANOMAS
MICE
MISONIDAZOLE
NEOPLASMS
NITRO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PRIMATES
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RECOVERY
REPAIR
RODENTS
VERTEBRATES