Effect of combined misonidazole and accelerated neon ions on a human melanoma transplanted into nude mice

Journal Article · Fri Jan 01 04:00:00 EST 1982 · Radiology; (United States)

DOI:https://doi.org/10.1148/radiology.142.1.6796997· OSTI ID:5401694

Guichard, M; Tenforde, T; Curtis, S; Malaise, E P

The response to accelerated neon ions of human Nall melanomas growing in nude mice was measured by an in vitro colony-forming assay following in situ tumor irradiation in the midposition of a 10-cm extended-peak ionization region. Values of the relative biological effectiveness (RBE) for peak neon ions compared with 60Co gamma radiation were 3.2 and 3.4, respectively, at the 1% and 10% survival levels. Following irradiation with peak neon ions, the repair of potentially lethal damage (PLD) was comparable to that observed after gamma irradiation. When misonidazole (1 mg/g intraperitoneal dose) was administered in combination with extended-peak neon ions, the drug enhancement ratio (ER) at the 1% survival level was 1.5 if the tumors were removed and plated in vitro immediately following irradiation, and 1.9 if tumor excision and plating were delayed for greater than 6 hours. Administration of misonidazole completely inhibited PLD repair following either gamma irradiation or extended-peak neon-ion irradiation.

• Research Organization: Institut Gustave-Roussy, Institut de Radiobiologie Clinique, Villejuif, France
• OSTI ID: 5401694
• Journal Information: Radiology; (United States), Journal Name: Radiology; (United States) Vol. 142:1; ISSN RADLA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTINEOPLASTIC DRUGS
AZOLES
BEAMS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CHARGED PARTICLES
COBALT 60
COBALT ISOTOPES
COLONY FORMATION
COMPARATIVE EVALUATIONS
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IN VITRO
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ION BEAMS
IONIZING RADIATIONS
IONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MELANOMAS
MICE
MINUTES LIVING RADIOISOTOPES
MISONIDAZOLE
NEON IONS
NEOPLASMS
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIATION EFFECTS
RADIATION QUALITY
RADIATIONS
RADIOISOTOPES
RADIOSENSITIZERS
RBE
RECOVERY
REPAIR
RODENTS
SURVIVAL CURVES
TRANSPLANTS
VERTEBRATES
YEARS LIVING RADIOISOTOPES