Effect of combined misonidazole and accelerated neon ions on a human melanoma transplanted into nude mice

Journal Article · Fri Jan 01 04:00:00 EST 1982 · Radiology; (United States)

DOI:https://doi.org/10.1148/radiology.142.1.6796997· OSTI ID:5638279

Guichard, M ^[1]; Tenforde, T; Curtis, S; Malaise, E P

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1. Institut de Radiobiologie Clinique, Villejuif, France

The response to accelerated neon ions of human Nall melanomas growing in nude mice was measured by an in vitro colony-forming assay following in situ tumor irradiation in the midposition of a 10-cm extended-peak ionization region. Values of the relative biological effectiveness (RBE) for peak neon ions compared with /sup 60/Co..gamma.. radiation were 3.2 and 3.4, respectively, at the 1% and 10% survival levels. Following irradiation with peak neon ions, the repair of potentially lethal damage (PLD) was comparable to that observed after ..gamma.. irradiation. When misonidazole (1 mg/g intraperitoneal dose) was administered in combination with extended-peak neon ions, the drug enhancement ratio (ER) at the 1% survival level was 1.5 if the tumors were removed and plated in vitro immediately following irradiation, and 1.9 if tumor excision and plating were delayed for greater than or equal to 6 hours. Administration of misonidazole completely inhibited PLD repair following either ..gamma.. irradiation or extended peak neon-ion irradiation.

• OSTI ID: 5638279
• Journal Information: Radiology; (United States), Journal Name: Radiology; (United States) Vol. 142:1; ISSN RADLA
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTINEOPLASTIC DRUGS
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CHARGED PARTICLES
CHEMOTHERAPY
COBALT 60
COBALT ISOTOPES
COMPARATIVE EVALUATIONS
DATA
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
GAMMA RADIATION
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MEDICINE
MELANOMAS
MICE
MINUTES LIVING RADIOISOTOPES
MISONIDAZOLE
NEON IONS
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIATIONS
RADIOISOTOPES
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RADIOTHERAPY
RBE
RECOVERY
REPAIR
RODENTS
THERAPY
TRANSPLANTS
VERTEBRATES
YEARS LIVING RADIOISOTOPES