Influence of misonidazole on the radiosensitivity of a human melanoma in nude mice: time-dependent increase in surviving fraction. [/sup 137/Cs. gamma. ]
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
Using an in vitro colony method, we tested the effect of 1 mg/g misonidazole on a human melanoma transplanted into a nude mice. The enhancement ratios were 1.6 when the cells were plated immediately after irradiation and 2.0 when plating was done after a delay of 6 hr. Whereas repair of potentially lethal damage (PLD) was demonstrated in cells without misonidazole, with the drug the surviving fraction was the same immediately or 6 hr after irradiation. Our interpretation of this finding is discussed.
- Research Organization:
- Institut Gustave-Roussy, Villejuif, France
- OSTI ID:
- 6145630
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 5:4; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ANIMAL CELLS
ANIMALS
ANOXIA
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CESIUM 137
CESIUM ISOTOPES
COLONY FORMATION
DATA
DATA FORMS
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
GAMMA RADIATION
HETEROCYCLIC COMPOUNDS
IMPLANTS
IN VITRO
IN VIVO
INFORMATION
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
ISOTOPES
MAMMALS
MELANOMAS
MICE
NEOPLASMS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RECOVERY
REPAIR
RESPONSE MODIFYING FACTORS
RODENTS
TIME DEPENDENCE
TOXICITY
TUMOR CELLS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ANIMAL CELLS
ANIMALS
ANOXIA
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CESIUM 137
CESIUM ISOTOPES
COLONY FORMATION
DATA
DATA FORMS
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
GAMMA RADIATION
HETEROCYCLIC COMPOUNDS
IMPLANTS
IN VITRO
IN VIVO
INFORMATION
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
ISOTOPES
MAMMALS
MELANOMAS
MICE
NEOPLASMS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RECOVERY
REPAIR
RESPONSE MODIFYING FACTORS
RODENTS
TIME DEPENDENCE
TOXICITY
TUMOR CELLS
VERTEBRATES
YEARS LIVING RADIOISOTOPES