Effect of mediastinal irradiation on cardiac function of patients treated during childhood and adolescence for Hodgkin's disease

Journal Article · Sun Feb 01 04:00:00 EST 1987 · J. Clin. Oncol.; (United States)

OSTI ID:6700676

Green, D M; Gingell, R L; Pearce, J; Panahon, A M; Ghoorah, J

To determine the frequency of cardiac dysfunction in patients treated during childhood or adolescence with mediastinal irradiation for Hodgkin's disease (HD), 28 patients underwent cardiac evaluation 19 to 182 months (median, 90 months) after the completion of radiation therapy. No patient had symptoms of cardiac disease. All were normotensive. All patients had a normal cardiothoracic ratio. There were no abnormalities of voltage or rhythm in the ECGs. The left ventricular end diastolic volume was increased in 19.2% of patients, none of whom had evidence of impaired left ventricular function. The left ventricular ejection fraction (LVEF) was increased in 15.3% of patients. No patient had a decreased LVEF. Pericardial thickening was demonstrated on echocardiograms from 12 of 28 patients (42.9%). Thickening was more frequent among those patients observed for 72 or more months (47.1%; eight of 17) than among those with shorter periods of follow-up (36.4%; four of 11). This study demonstrates that cardiac dysfunction is an infrequent sequela of mediastinal irradiation following treatment using an equally weighted, anterior-posterior technique. Longitudinal study of these patients will be necessary to determine the clinical significance and evolution of the occult pericardial thickening that was identified.

• Research Organization: Roswell Park Memorial Institute, Buffalo, NY
• OSTI ID: 6700676
• Journal Information: J. Clin. Oncol.; (United States), Journal Name: J. Clin. Oncol.; (United States) Vol. 2; ISSN JCOND
• Country of Publication: United States
• Language: English

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADOLESCENTS
AGE GROUPS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CARDIOVASCULAR SYSTEM
CHEST
CHILDREN
DELAYED RADIATION EFFECTS
DISEASES
HEART
HODGKINS DISEASE
LYMPHOMAS
MEDIASTINUM
MEDICINE
MEMBRANES
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
PERICARDIUM
RADIATION EFFECTS
RADIOLOGY
RADIOTHERAPY
SEROUS MEMBRANES
SIDE EFFECTS
THERAPY