Long-term follow-up of cardiac function in patients with Hodgkin's disease treated with mediastinal irradiation and combination chemotherapy including doxorubicin

Journal Article · Tue Apr 01 04:00:00 EST 1986 · Cancer Treat. Rep.; (United States)

OSTI ID:5489461

LaMonte, C S; Yeh, S D; Straus, D J

Among 41 evaluable patients whose first treatment for advanced Hodgkin's disease had consisted of alternating cycles of mechlorethamine, vincristine, prednisone, and procarbazine (MOPP), and doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD), in addition to low-dose mediastinal irradiation, 19 underwent retrospective cardiac evaluation by routine posteroanterior and lateral chest x-ray, 12-lead ECG, M-mode echocardiogram, and ECG-gated left ventricular blood pool scan at rest and during exercise. Fifteen patients had unequivocally normal left ventricular function by all these parameters. Two patients had minimally reduced left ventricular ejection fraction (LVEF) at rest with a normal increment with exercise. In two other patients with high normal resting LVEF and subnormal increment with exercise, the elevated resting values implied initial measurement in a nonbasal state. A twentieth patient (the oldest; one of two with active Hodgkin's disease at the time of evaluation and the stimulus for this study) had markedly reduced LVEF as determined by radionuclide cardiac angiography and had developed clinical congestive heart failure shortly before evaluation. Despite this patient, the study indicates that treatment with MOPP/ABVD and low-dose mediastinal irradiation entails low risk for cardiac complications.

• Research Organization: Memorial Sloan-Kettering Cancer Center, New York, NY
• OSTI ID: 5489461
• Journal Information: Cancer Treat. Rep.; (United States), Journal Name: Cancer Treat. Rep.; (United States) Vol. 4; ISSN CTRRD
• Country of Publication: United States
• Language: English

Related Subjects

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62 RADIOLOGY AND NUCLEAR MEDICINE
ADRENAL HORMONES
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTINEOPLASTIC DRUGS
BLOOD PRESSURE
BODY
CARDIOVASCULAR SYSTEM
CHEMOTHERAPY
COMBINED THERAPY
CORTICOSTEROIDS
DIAGRAMS
DISEASES
DOXORUBICIN
DRUGS
DYNAMIC FUNCTION STUDIES
ELECTROCARDIOGRAMS
EXERCISE
GLUCOCORTICOIDS
HEART
HODGKINS DISEASE
HORMONES
HYDROXY COMPOUNDS
IRRADIATION
KETONES
LOW DOSE IRRADIATION
LYMPHOMAS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PREDNISONE
PREGNANES
RADIOLOGY
RADIOTHERAPY
RISK ASSESSMENT
STEROID HORMONES
STEROIDS
THERAPY