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Cardiac disease after radiation therapy for Hodgkin's disease: analysis of 48 patients

Journal Article · · Am. J. Cardiol.; (United States)
;
Occult or overt but delayed cardiac disease after thoracic radiotherapy for Hodgkin's disease may be common. Detailed cardiac evaluations were performed in 48 patients with Hodgkin's disease at risk a mean of 97 months after radiotherapy. The study protocol included echocardiography, gated radionuclide ventriculography, and cardiac catheterization. Cardiac disease was found in 46 patients (96%) and included constrictive or occult constrictive pericarditis (24 patients), an abnormal hemodynamic response to a fluid challenge (14 patients), coronary artery disease (6 patients), and left ventricular dysfunction (2 patients). Most patients (53%) had normal echocardiograms. Gated blood pool radionuclide angiocardiography was performed in 42 patients. Excluding patients with occlusive coronary artery disease, the left ventricular ejection fraction at rest (mean 59%) and during exercise (mean 69%) was within normal limits. Thus (1) delayed cardiac disease after radiotherapy is common, (2) chronic pericardial disorders are the most frequent manifestations of this disease, and (3) the prognosis for patients who have radiation-induced cardiac disease is generally favorable.
Research Organization:
Univ. of Maryland Hospital, Baltimore
OSTI ID:
5096461
Journal Information:
Am. J. Cardiol.; (United States), Journal Name: Am. J. Cardiol.; (United States) Vol. 51:10; ISSN AJCDA
Country of Publication:
United States
Language:
English

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Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CARDIOGRAPHY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHEST
DELAYED RADIATION EFFECTS
DIAGNOSTIC TECHNIQUES
DISEASES
HEART
HODGKINS DISEASE
LYMPHOMAS
MEDICINE
MEMBRANES
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
PERICARDIUM
RADIATION EFFECTS
RADIOCARDIOGRAPHY
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
SEROUS MEMBRANES
SIDE EFFECTS
THERAPY