Late appearance of chronic pericardial disease in patients treated by radiotherapy for Hodgkin's disease

Journal Article · Sun Mar 01 04:00:00 EST 1981 · Ann. Intern. Med.; (United States)

DOI:https://doi.org/10.7326/0003-4819-94-3-338· OSTI ID:5513764

Applefeld, M M; Cole, J F; Pollock, S H; Sutton, F J; Slawson, R G; Singleton, R T; Wiernik, P H

Radiation-induced chronic pericardial disease was recognized in nine patients 53 to 124 months (mean, 88 months) after radiotherapy for Hodgkin's disease. Depending on whether abnormal cardiac hemodynamics occurred before or after a fluid challenge, patients were considered to have either constrictive pericarditis (Group I) or occult constrictive pericarditis (Group II). There were no differences between these groups in various radiotherapy data, the use of chemotherapy, or the interval after treatment when the diagnosis of chronic pericardial disease was made. There were no consistent noninvasive variables to support the diagnosis of radiation-induced chronic pericardial disease before cardiac catheterization. Four patients underwent pericardiectomy. Two of the four operated patients had an excellent surgical result; a third patient died 4 months postoperatively of drug-induced granulocytopenia; the fourth patient has persistent visceral constrictive pericarditis 18 months after surgery. Speculation over the causes of radiation-induced chronic pericardial disease is made and our recommendations for its treatment given.

• OSTI ID: 5513764
• Journal Information: Ann. Intern. Med.; (United States), Journal Name: Ann. Intern. Med.; (United States) Vol. 94:3; ISSN AIMEA
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
551000 -- Physiological Systems
560151 -- Radiation Effects on Animals-- Man
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHEMOTHERAPY
DIAGNOSIS
DISEASES
HEART
HODGKINS DISEASE
LYMPHOMAS
MEDICINE
MEMBRANES
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
PERICARDIUM
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
RECOMMENDATIONS
SEROUS MEMBRANES
THERAPY