Iridium-191 angiocardiography for the detection and quantitation of left-to-right shunting

Journal Article · Mon Dec 01 04:00:00 EST 1980 · J. Nucl. Med.; (United States)

OSTI ID:6677291

Treves, S; Cheng, C; Samuel, A; Lambrecht, R; Babchyck, B; Zimmerman, R; Norwood, W

An osmium-191 ..-->.. iridium-191 generator that can deliver multiple doses of Ir-191m for first-pass radionuclide angiography has been developed. Iridium-191m has a physical half-life of 4.96 sec and decays with emission of 65-keV and 129-keV photons in 58 and 30% abundance, respectively. Using a gamma camera, Ir-191m radionuclide angiography was carried out, in dogs and ten patients, for the detection and quantitation of left-to-right shunting. In a one-year-old patient, 25 mCi of Ir-191m results in a whole-body radiation absorbed dose of 35 mrad. Multiple Ir-191m angiograms can be performed, seconds to minutes apart, without interference from background. The 15.4-day half-life of Os-191 permits transportation of the generator to centers far from the production facility. With the low radiation dose, high information density, and the ability to repeat studies with Ir-191m, clinical use of radionuclide angiography should be expanded.

• Research Organization: Harvard Medical School, Boston, MA
• OSTI ID: 6677291
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 21:12; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702 -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL HALF-LIFE
CAMERAS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
DOGS
DOSES
DYNAMIC FUNCTION STUDIES
EVEN-ODD NUCLEI
GAMMA CAMERAS
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IRIDIUM 191
IRIDIUM ISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
OSMIUM 191
OSMIUM ISOTOPES
PATIENTS
RADIATION DOSES
RADIOISOTOPE GENERATORS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
STABLE ISOTOPES
TECHNETIUM 99
TECHNETIUM ISOTOPES
USES
VERTEBRATES
YEARS LIVING RADIOISOTOPES