Detection and quantitation of left-to-right shunting by iridium-191m angiography

Conference · Thu Jan 01 04:00:00 EST 1981

OSTI ID:6306617

Treves, S; Cheng, C; Samuel, A; Fuji, A; Lambrecht, R

An osmium-191..-->..iridium-191m radionuclide generator suitable for first-pass angiography has been developed. Osmium-191 with a physical half-life of 15.4 days is produced in the reactor by the /sup 190/Os(eta, ..gamma..)/sup 191/Os reaction and decays by internal conversion to /sup 191/Ir/sup m/. Iridium-191m has a physical half-life of 4.96 s and decays by isometric transition to stable /sup 191/Ir. It emits a gamma ray at 129 keV with 30% abundance. In addition, x-rays at about keV in 58% abundance are emitted as a result of internal conversion from the 129 keV excited state. Osmium-191 metal is converted into potassium osmate, which is loaded into a column of 0.9 m1 of AGMP-1 anion exchange resin. This column is connected in series to another column also of 0.9 m1 of Dowex-2 and pyrocatechol. The generator is eluted with 0.6 to 1 m1 of 0.9% NaCl, pH 1. One m1 of eluant yields 7 to 10% of the /sup 191/Ir/sup m/ in the column and there is a 3 to 5% x 10/sup -3/% of /sup 191/Os breakthrough. The eluant is rapidly diluted and flushed with a buffer solution (25% 0.05M Na/sub 2/HPO/sub 4/, 75% 0.9% NaC1) before injection. The lowest pH delivered is 3.5. First-pass radionuclide angiography has been carried out in 59 patients ranging from four days to 67 years of age (mean = 14 years) for detection and quantitation of left-to-right shunting. Twelve patients underwent cardiac catheterizations with simultaneous /sup 191/Ir/sup m/ angiography. They had pulmonary-to-systemic ratios (Qp:Qs) ranging from 1.04 to 3.00. The major advantages of /sup 191/Ir/sup m/ are low radiation dose to patients high photon flux and the possibility of obtaining repeated studies within a short time. 22 refs., 3 figs.

• Research Organization: Harvard Medical School, Boston, MA (USA); Children's Hospital Medical Center, Boston, MA (USA); Massachusetts Inst. of Tech., Cambridge (USA); Brookhaven National Lab., Upton, NY (USA)
• DOE Contract Number: AC02-76CH00016
• OSTI ID: 6306617
• Report Number(s): IAEA-SM-247/19; CONF-800937-4; ON: DE86005121
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400703* -- Radiochemistry & Nuclear Chemistry-- Radioisotope Production
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CHROMATOGRAPHY
DAYS LIVING RADIOISOTOPES
DESIGN
DIAGNOSTIC USES
ELECTROMAGNETIC RADIATION
EVEN-ODD NUCLEI
GAMMA RADIATION
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
ION EXCHANGE CHROMATOGRAPHY
IONIZING RADIATIONS
IRIDIUM 191
IRIDIUM ISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
OSMIUM 191
OSMIUM ISOTOPES
PATIENTS
PERFORMANCE TESTING
RADIATIONS
RADIOISOTOPE GENERATORS
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
SEPARATION PROCESSES
STABLE ISOTOPES
TESTING
USES
X RADIATION