Osmium-191. -->. iridium-191m radionuclide generator: development and clinical application. Progress report, March 1, 1981-February 28, 1982

Technical Report · Thu Jan 01 04:00:00 EST 1981

OSTI ID:5245007

Treves, S; Cheng, C

A prototype osmium-191 (T 1/2 = 16 days) ..-->.. iridium-191m (T 1/2 = 4.9 seconds) generator designed for first pass radionuclide angiography was developed in our laboratory (Os-191 ..-->.. Ir-191m). Our generator had 14 to 20% Ir-191m yield and a 1 to 3 x 10/sup -3/% Os-191 breakthrough. Iridium-191m decays with emission of a 65 and a 129 keV photon in 50% and 25% abundance respectively. This radionuclide is advantageous for angiography since it provides higher photon flux and results in much lower radiation dose to the patient than Tc-99m. One objective of this research is to improve the Os-191 ..-->.. Ir-191m generator for first pass radionuclide angiography at an increase in the Ir-191m yield and a decrease in the Os-191 breakthrough. In addition, we would like to develop an Os-191 ..-->.. Ir-191m generator for continuous infusion which will be used for ECG gated blood pool ventriculography, venography, and arteriography. Another approach will be to develop a carrier free Os-191 ..-->.. Ir-191m generator in combination with organic or inorganic exchangers. Iridium-191m from our current generator has been employed successfully in two patient studies for the quantitation left-to-right shunting and the measurement of right and left ventricular ejection fractions. These types of studies will be expanded and further evaluated.

• Research Organization: Massachusetts Inst. of Tech., Cambridge (USA); Children's Hospital Medical Center, Boston, MA (USA)
• DOE Contract Number: AS02-76EV04115
• OSTI ID: 5245007
• Report Number(s): DOE/EV/04115-T1; ON: DE82007649
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
ENERGY RANGE
EVEN-ODD NUCLEI
HEART
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
IRIDIUM 191
IRIDIUM ISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KEV RANGE
KEV RANGE 10-100
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
OPTIMIZATION
ORGANS
OSMIUM 191
OSMIUM ISOTOPES
PATIENTS
RADIOISOTOPE GENERATORS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
STABLE ISOTOPES