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Title: Osmium-191. -->. iridium-191m radionuclide generator: development and clinical application. Progress report, March 1, 1981-February 28, 1982

Abstract

A prototype osmium-191 (T 1/2 = 16 days) ..-->.. iridium-191m (T 1/2 = 4.9 seconds) generator designed for first pass radionuclide angiography was developed in our laboratory (Os-191 ..-->.. Ir-191m). Our generator had 14 to 20% Ir-191m yield and a 1 to 3 x 10/sup -3/% Os-191 breakthrough. Iridium-191m decays with emission of a 65 and a 129 keV photon in 50% and 25% abundance respectively. This radionuclide is advantageous for angiography since it provides higher photon flux and results in much lower radiation dose to the patient than Tc-99m. One objective of this research is to improve the Os-191 ..-->.. Ir-191m generator for first pass radionuclide angiography at an increase in the Ir-191m yield and a decrease in the Os-191 breakthrough. In addition, we would like to develop an Os-191 ..-->.. Ir-191m generator for continuous infusion which will be used for ECG gated blood pool ventriculography, venography, and arteriography. Another approach will be to develop a carrier free Os-191 ..-->.. Ir-191m generator in combination with organic or inorganic exchangers. Iridium-191m from our current generator has been employed successfully in two patient studies for the quantitation left-to-right shunting and the measurement of right and left ventricular ejection fractions. These typesmore » of studies will be expanded and further evaluated.« less

Authors:
;
Publication Date:
Research Org.:
Massachusetts Inst. of Tech., Cambridge (USA); Children's Hospital Medical Center, Boston, MA (USA)
OSTI Identifier:
5245007
Report Number(s):
DOE/EV/04115-T1
ON: DE82007649; TRN: 82-013991
DOE Contract Number:  
AS02-76EV04115
Resource Type:
Technical Report
Resource Relation:
Other Information: Portions of document are illegible
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; HEART; SCINTISCANNING; IRIDIUM 191; RADIOISOTOPE GENERATORS; OPTIMIZATION; ISOMERIC NUCLEI; KEV RANGE 10-100; OSMIUM 191; PATIENTS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CARDIOVASCULAR SYSTEM; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; ENERGY RANGE; EVEN-ODD NUCLEI; HEAVY NUCLEI; HOURS LIVING RADIOISOTOPES; IRIDIUM ISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; KEV RANGE; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANS; OSMIUM ISOTOPES; RADIOISOTOPE SCANNING; RADIOISOTOPES; SECONDS LIVING RADIOISOTOPES; STABLE ISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Treves, S, and Cheng, C. Osmium-191. -->. iridium-191m radionuclide generator: development and clinical application. Progress report, March 1, 1981-February 28, 1982. United States: N. p., 1981. Web.
Treves, S, & Cheng, C. Osmium-191. -->. iridium-191m radionuclide generator: development and clinical application. Progress report, March 1, 1981-February 28, 1982. United States.
Treves, S, and Cheng, C. Thu . "Osmium-191. -->. iridium-191m radionuclide generator: development and clinical application. Progress report, March 1, 1981-February 28, 1982". United States.
@article{osti_5245007,
title = {Osmium-191. -->. iridium-191m radionuclide generator: development and clinical application. Progress report, March 1, 1981-February 28, 1982},
author = {Treves, S and Cheng, C},
abstractNote = {A prototype osmium-191 (T 1/2 = 16 days) ..-->.. iridium-191m (T 1/2 = 4.9 seconds) generator designed for first pass radionuclide angiography was developed in our laboratory (Os-191 ..-->.. Ir-191m). Our generator had 14 to 20% Ir-191m yield and a 1 to 3 x 10/sup -3/% Os-191 breakthrough. Iridium-191m decays with emission of a 65 and a 129 keV photon in 50% and 25% abundance respectively. This radionuclide is advantageous for angiography since it provides higher photon flux and results in much lower radiation dose to the patient than Tc-99m. One objective of this research is to improve the Os-191 ..-->.. Ir-191m generator for first pass radionuclide angiography at an increase in the Ir-191m yield and a decrease in the Os-191 breakthrough. In addition, we would like to develop an Os-191 ..-->.. Ir-191m generator for continuous infusion which will be used for ECG gated blood pool ventriculography, venography, and arteriography. Another approach will be to develop a carrier free Os-191 ..-->.. Ir-191m generator in combination with organic or inorganic exchangers. Iridium-191m from our current generator has been employed successfully in two patient studies for the quantitation left-to-right shunting and the measurement of right and left ventricular ejection fractions. These types of studies will be expanded and further evaluated.},
doi = {},
url = {https://www.osti.gov/biblio/5245007}, journal = {},
number = ,
volume = ,
place = {United States},
year = {1981},
month = {1}
}

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