/sup 228/Th retention and dosimetry in beagles

Journal Article · Fri Jun 01 00:00:00 EDT 1984 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576493· OSTI ID:6657079

Lloyd, R D; Jones, C W; Mays, C W; Atherton, D R; Bruenger, F W; Taylor, G N

Total-body and skeletal retention of /sup 228/Th were determined in a group of 104 young adult male and female beagles for about the first 7 years after the injection of 0.00159 to 2.76 ..mu..Ci/kg. Ratios of /sup 224/Ra//sup 228/Th, /sup 212/Pb//sup 228/Th, and /sup 212/Bi//sup 228/Th in the skeleton and in soft tissues of 20 beagles were measured as a function of time after injection. A humerus, femur, and ulna from 20 dogs dying 7 to 554 days after injection were sectioned, and the /sup 228/Th concentration was obtained for each piece. Ratios of daughter-to-parent activity in soft tissue showed no definite trend with dose level or time and averaged Ra/Th = 0.56, Pb/Th = 0.83, and Bi/Th = 0.91, whereas the ratios for the skeleton varied with both dose level and time. Retained /sup 228/Th was deposited most heavily in parts of the skeleton with much trabecular bone, much bone surface area, and high bone remodeling rates. No changes in this deposition pattern could be discerned during the 554 days over which the measurements of sectioned long bones were made.

• Research Organization: Univ. of Utah, Salt Lake City
• DOE Contract Number: AC02-76EV00119
• OSTI ID: 6657079
• Journal Information: Radiat. Res.; (United States), Vol. 98:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BISMUTH 212
ISOTOPE RATIO
LEAD 212
RADIUM 224
SKELETON
RADIONUCLIDE KINETICS
THORIUM 228
RETENTION
BEAGLES
INTRAVENOUS INJECTION
RADIATION DOSES
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALKALINE EARTH ISOTOPES
ALPHA DECAY RADIOISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BISMUTH ISOTOPES
BODY
DAYS LIVING RADIOISOTOPES
DOGS
DOSES
EVEN-EVEN NUCLEI
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INJECTION
INTAKE
ISOTOPES
LEAD ISOTOPES
MAMMALS
NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIOISOTOPES
RADIUM ISOTOPES
THORIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560172* - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)