Radiation dose rates to the proximal humerus of growing beagles injected with /sup 239/Pu
The anatomical distribution of /sup 239/Pu in the proximal humerus was studied in four beagles injected at 90 days of age and sacrificed 7, 28, 56, and 128 days after injection, respectively. Initial deposition in each humerus was 3.1% of the injected Pu; 41% of that was retained with a net halftime of 248 days; for the remaining 59% no decrease was observed with time. Sixty-one percent of the initial deposit was concentrated in the proximal epiphysis and metaphysis. Average radiation dose rates to trabecular bone of the epiphysis, to those parts of the metaphysis that were formed before and/or after injection, and to the area corresponding to the primary and secondary spongiosa were determined by fission track autoradiography. Local dose rates within the range of 10 ..mu..m of the endosteal surface, to the marrow and to osseous tissue were calculated. The possible effects of local radiation doses were correlated with areal densities of cells and types of cells at risk. Comparisons were made with corresponding sites from the humerus of beagles injected as young adults.
- Research Organization:
- Univ. of Utah, Salt Lake City
- DOE Contract Number:
- AC02-76EV00119
- OSTI ID:
- 5173259
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 97:2; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Microdistribution and retention of injected /sup 239/Pu on trabecular bone surfaces of the beagle: implications for the induction of osteosarcoma
/sup 228/Th retention and dosimetry in beagles
Related Subjects
560162 -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANIMAL TISSUES
ANIMALS
AUTORADIOGRAPHY
BEAGLES
BODY
BODY AREAS
BONE MARROW
BONE TISSUES
CARBOXYLIC ACID SALTS
CITRATES
CONNECTIVE TISSUE
DATA
DOGS
DOSE RATES
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
FISSION TRACKS
HEAVY NUCLEI
HEMATOPOIETIC SYSTEM
INFORMATION
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOTOPES
LIMBS
MAMMALS
NUCLEI
NUMERICAL DATA
ORGANS
PARTICLE TRACKS
PLUTONIUM 239
PLUTONIUM ISOTOPES
RADIOISOTOPES
RADIONUCLIDE KINETICS
SKELETON
TISSUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES