Microdistribution and retention of injected /sup 239/Pu on trabecular bone surfaces of the beagle: implications for the induction of osteosarcoma

Journal Article · Tue Jul 01 00:00:00 EDT 1980 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575260· OSTI ID:5129062

Wronski, T J; Smith, J M; Jee, W S.S.

A study was initiated to investigate the relationship between skeletal remodeling and the microdistribution and retention of /sup 239/Pu on trabecular bone surfaces of the beagle, and the contribution of these parameters to the nonuniform skeletal distribution of /sup 239/Pu-induced osteosarcomas. Young adult beagles were administered single iv injections of approx. 0.016 ..mu..Ci/kg monomeric /sup 239/Pu citrate and sacrificed at various times to 1 year after injection. The /sup 239/Pu concentration on trabecular bone surfaces was determined by counting fission fragment tracks in neutron-induced autoradiographs produced from thick (approx. 400 ..mu..m) bone sections. The rate of trabecular bone formation was calculated from an ultraviolet microscopic analysis of fluorescent tetracycline labels. The lumbar vertebra, pelvis, and proximal humerus, each of which exhibits a high incidence of /sup 239/Pu-induced osteosarcoma, were found to have a high intial concentration of /sup 239/Pu on their trabecular surfaces (approx. 7-8 pCi/cm/sup 2/) and a relatively high rate of trabecular bone formation. The /sup 239/Pu concentration at these sites decreased to approx. 2-3 pCi/cm/sup 2/ at the end of the first year. On the other hand, the proximal ulna and distal humerus, skeletal sites with a low tumor incidence, had a low intial concentration of /sup 239/Pu on their trabecular surfaces(approx. 1-2 pCi/cm/sup 2/) and a significantly lower rate of trabecular bone formation (P < 0.01). The /sup 239/Pu concentration at these sites remained nearly constant throughout the experimental period. These data suggest that the degree of the initial deposition of /sup 239/Pu on trabecular bone surfaces and the rate of trabecular bone turnover may play a role in the genesis of /sup 239/Pu-induced osteosarcomas.

• Research Organization: Univ. of Utah, Salt Lake City
• OSTI ID: 5129062
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 83:1; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

551000 -- Physiological Systems
560162* -- Radionuclide Effects
Kinetics
&amp; Toxicology-- Animals
Plants
Microorganisms
&amp; Cells
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANIMALS
BEAGLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE TISSUES
CONNECTIVE TISSUE
DATA
DISEASES
DISTRIBUTION
DOGS
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
HEAVY NUCLEI
INFORMATION
INJECTION
INTAKE
INTERNAL IRRADIATION
INTRAVENOUS INJECTION
IRRADIATION
ISOTOPES
MAMMALS
NEOPLASMS
NUCLEI
NUMERICAL DATA
ORGANS
OSTEOSARCOMAS
PLUTONIUM 239
PLUTONIUM ISOTOPES
RADIATION EFFECTS
RADIOINDUCTION
RADIOISOTOPES
RADIONUCLIDE KINETICS
RETENTION
SARCOMAS
SKELETAL DISEASES
SKELETON
TISSUE DISTRIBUTION
TISSUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES