Relationship of bone marrow type and microvasculature of the microdistribution and local dosimetry of plutonium in the adult skeleton. [Beagles]

Journal Article · Wed Aug 01 04:00:00 EDT 1984 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576375· OSTI ID:6538776

Smith, J M; Miller, S C; Jee, W S.S.

Most plutonium-induced bone tumors in beagles arise in trabecular bone sites surrounded by hematopoietic tissue. The microvasculature and the relative incorporation of /sup 241/Pu (a low energy ..beta.. emitter) on trabecular bone surfaces from red and fatty marrow sites were studied in the adult beagle. The vascular volume, as determined by India ink perfusion, was about 16% in the red marrow and about 2% in the fatty marrow. Plutonium concentrations on bone surfaces of red marrow sites are about 0.43 pCi/cm/sup 2//nCi/kg of injected dosage, a factor of eight greater than at fatty marrow sites. The differences in the bone marrow microvasculature between red and fatty marrow help to explain differences in plutonium incorporation and local bone physiology in these skeletal sites. These observations may relate to the nonuniform distribution of plutonium-induced osteosarcomas observed in adult, long-lived mammals.

• Research Organization: Univ. of Utah School of Medicine, Salt Lake City
• OSTI ID: 6538776
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 99:2; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ALPHA DOSIMETRY
ANIMAL TISSUES
ANIMALS
AUTORADIOGRAPHY
BEAGLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD VESSELS
BODY
BONE MARROW
CAPILLARIES
CARBOXYLIC ACID SALTS
CARDIOVASCULAR SYSTEM
CITRATES
DATA
DISEASES
DISTRIBUTION
DOGS
DOSIMETRY
ELECTRON MICROSCOPY
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
HEAVY NUCLEI
HEMATOPOIETIC SYSTEM
INFORMATION
ISOTOPES
MAMMALS
MICROSCOPY
NEOPLASMS
NUCLEI
NUMERICAL DATA
ORGANS
OSTEOSARCOMAS
PLUTONIUM 239
PLUTONIUM 241
PLUTONIUM ISOTOPES
RADIOINDUCTION
RADIOISOTOPES
SARCOMAS
SKELETAL DISEASES
TISSUE DISTRIBUTION
TISSUES
TRANSMISSION ELECTRON MICROSCOPY
VERTEBRATES
YEARS LIVING RADIOISOTOPES