Bone structural parameters, dosimetry, and relative radiation risk in the beagle skeleton

Journal Article · Sun Oct 01 00:00:00 EDT 1989 · Radiation Research; (USA)

DOI:https://doi.org/10.2307/3577636· OSTI ID:5183178

Polig, E; Jee, W S ^[1]

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1. Institut fuer Genetik und fuer Toxikologie von Spaltstoffen, Karlsruhe (Germany, F.R.)

A variety of morphometric and histomorphometric parameters such as the mass of bone and marrow, bone surface areas, percentage of bone volume, percentage of the surface that is trabecular, and percentage of surfaces that are forming and resting are calculated for all major parts of the beagle skeleton. The total bone surface of the beagle is estimated at 2.9 m2 with 53.7% of the surface area being associated with trabecular bone. There are about 4.5 x 10(9) bone-lining cells and about 1 x 10(9) osteoblasts. From the fractional retention in each part of the skeleton, the initial surface concentration of 239Pu after a single injection of 592 Bq/kg body wt (0.016 microCi/kg) on resting surfaces and at sites of bone formation is calculated for various values of the affinity ratios of trabecular/cortical and forming/resting surfaces. These estimated concentrations then yield dose rates as well as cumulative and collective doses to bone-lining cells and osteoblasts in the different parts of the skeleton. On the assumption that the relative risk of tumor induction is proportional to the collective dose to either bone-lining cells or osteoblasts, the frequency of tumor occurrence is calculated and compared to observed frequencies. Both hypotheses yield approximate agreement with experimental data for different ratios of trabecular/cortical radiation sensitivity, although the differences between some bones are statistically significant.

• OSTI ID: 5183178
• Journal Information: Radiation Research; (USA), Journal Name: Radiation Research; (USA) Vol. 120:1; ISSN RAREA; ISSN 0033-7587
• Country of Publication: United States
• Language: English

Related Subjects

560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANIMALS
BEAGLES
BODY
DISEASES
DOGS
DOSES
EVEN-ODD NUCLEI
HEAVY NUCLEI
ISOTOPES
MAMMALS
NEOPLASMS
NUCLEI
ORGANS
PLUTONIUM 239
PLUTONIUM ISOTOPES
RADIATION DOSES
RADIOINDUCTION
RADIOISOTOPES
RISK ASSESSMENT
SKELETON
VERTEBRATES
YEARS LIVING RADIOISOTOPES