Radium-224 retention, distribution, and dosimetry in beagles

Journal Article · Sun Oct 31 23:00:00 EST 1982 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576005· OSTI ID:6425824

Lloyd, R D; Mays, C W; Taylor, G N; Atherton, D R; Bruenger, F W; Jones, C W

The retention, distribution, and dosimetry of injected /sup 224/Ra were studied in six young adult beagles killed 0.04 to 7 days after /sup 224/Ra administration. Biological retention of /sup 224/Ra in the skeleton averaged 48% (37 to 60%), and soft-tissue retention decreased from 61% at 0.04 days to 6% at 7 days. At death there was more /sup 212/Pb in red blood cells and liver than the amount in transient equilibrium with the /sup 224/Ra in these tissues. There was an excess of 2/sup 12/Bi over /sup 224/Ra in kidneys, and a deficiency of both 2/sup 12/Pb and /sup 212/Bi relative to /sup 224/Ra in eyes and bone. The retention equations derived from the data suggest that the fractional escape of /sup 220/Rn produced in bone by /sup 224/Ra decay was roughly 0.08. From the retention of /sup 224/Ra, /sup 212/Pb, and /sup 212/Bi in the skeleton and selected soft tissues, it was calculated that the injection of 1 ..mu..Ci /sup 224/Ra/kg into an adult beagle having 75 g skeleton/kg body results in cumulative average doses to the blood-filled organs of 40 rad to the skeleton, 13 rad to the kidneys, 8 rad to the liver, 11 rad to the eyes, and 0.8 rad to the testes and ovaries.

• Research Organization: Univ. of Utah, Salt Lake City
• OSTI ID: 6425824
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 92:2; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH ISOTOPES
ALPHA DECAY RADIOISOTOPES
ANIMALS
BEAGLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BISMUTH 212
BISMUTH ISOTOPES
BLOOD
BLOOD CELLS
BODY
BODY AREAS
BODY FLUIDS
DAUGHTER PRODUCTS
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
DOGS
DOSES
DOSIMETRY
ERYTHROCYTES
EVEN-EVEN NUCLEI
EYES
FACE
GLANDS
HEAD
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
ISOTOPES
KIDNEYS
LEAD 212
LEAD ISOTOPES
LIVER
MAMMALS
MATERIALS
NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIATION DOSES
RADIOISOTOPES
RADIUM 224
RADIUM ISOTOPES
RADON 220
RADON ISOTOPES
RETENTION
SECONDS LIVING RADIOISOTOPES
SENSE ORGANS
SKELETON
TISSUE DISTRIBUTION
VERTEBRATES