Effects of butylated hydroxyanisole on the metabolism and mutagenic and transformation potentials of benzo(a)-pyrene in cultured mammalian cells

Conference · Thu Dec 31 23:00:00 EST 1981

OSTI ID:6642581

Chen, D J; Okinaka, R T; Strniste, G F

The mechanism by which butylated hydroxyanisole (BHA) inhibits benzo(a)pyrene (BaP)-induced neoplasia in vivo and mutagenicity in vitro has been the subject of a number of investigations. In this study the effect of BHA on BaP metabolism in Syrian hamster embryonic (SHE) cells was studied. In addition, a SHE cell-mediated Chinese hamster ovary (CHO) cell mutagenesis and a SHE cell transformation assay have been used to study the biological effects of BHA. The results indicate that BHA reduces the metabolism of BaP in SHE cells, suppresses BaP-induced mutagenicity in target CHO cells and reduces morphological transformation by BaP in SHE cells. (ACR)

• Research Organization: Los Alamos National Lab., NM (USA)
• DOE Contract Number: W-7405-ENG-36
• OSTI ID: 6642581
• Report Number(s): LA-UR-82-3387; CONF-8210100-1; ON: DE83003531
• Country of Publication: United States
• Language: English

Related Subjects

560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANISOLE
AROMATICS
BENZOPYRENE
BIOLOGICAL EFFECTS
CARCINOGENESIS
CELL CULTURES
CONDENSED AROMATICS
ETHERS
HAMSTERS
HYDROCARBONS
HYDROXY COMPOUNDS
MAMMALS
METABOLISM
MUTAGEN SCREENING
MUTAGENESIS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PATHOGENESIS
RODENTS
SCREENING
VERTEBRATES