Acetylcholinesterase fluctuations in central nervous system of rat during methylmercury intoxication and chelation therapy

Journal Article · · Journal of Environmental Pathology, Toxicology and Oncology; (United States)

OSTI ID:6640683

Sood, P P; Raghu, K G; Bapu, C; Vijayalakshmi, K ^[1]

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1. Saurashtra Univ., Rajkot (India)

A daily dose of 1 mg/kg and 10 mg/kg of methylmercury chloride (MMC) was injected to separate sets of rats for 2 days, 7 days, and 15 days. Low and high doses of four MMC antagonists, namely N-acetyl-DL-homocysteine thiolactone (NAHT), glutathione (GSH), D-penicillamine (DPA), and sodium selenite (SEL) were injected intramuscularly (i.m.) to MMC-treated animals after an interval of half an hour. The animals were sacrificed on the 3rd, 8th, and 16th day, respectively. An additional group of rats was treated with MMC for 7 days; thereafter, it was kept free of toxic exposure for 7 days and sacrificed on the 15th day. The brain was dissected and separated into olfactory bulbs, cerebral hemispheres, cerebellum, and medulla oblongata. Each part of the central nervous system (CNS) was studied separately. We found a dose- and duration-related acetylcholinesterase (AChE) inhibition in all CNS areas. The use of antagonists showed different effects in different CNS areas, but no appreciable recovery of AChE activity could be obtained with the doses used. 23 refs., 2 figs., 2 tabs.

• OSTI ID: 6640683
• Journal Information: Journal of Environmental Pathology, Toxicology and Oncology; (United States), Journal Name: Journal of Environmental Pathology, Toxicology and Oncology; (United States) Vol. 12:3; ISSN 0731-8898; ISSN JEPOEC
• Country of Publication: United States
• Language: English

Related Subjects

550200 -- Biochemistry
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL COMPOUNDS
AMINO ACIDS
ANIMALS
BODY
BRAIN
CARBOXYLESTERASES
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CHALCOGENIDES
CHELATING AGENTS
CHOLINESTERASE
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ENZYME INHIBITORS
ENZYMES
ESTERASES
GLUTATHIONE
HOMOCYSTEINE
HYDROLASES
INHIBITION
MAMMALS
METHYLMERCURY
NERVOUS SYSTEM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PENICILLAMINE
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIOPROTECTIVE SUBSTANCES
RATS
RODENTS
SELENIDES
SELENIUM COMPOUNDS
SODIUM COMPOUNDS
SODIUM SELENIDES
THIOLS
TOXICITY
VERTEBRATES