Methylmercury chloride-induced and antagonist-reverted succinic dehydrogenase changes in the brain and trigeminal ganglia of the rat
Journal Article
·
· Environ. Res.; (United States)
The effect of methylmercury chloride (MMC) toxicity and its antagonism by chelating agents (N-acetyl-DL-homocysteine thiolactone and 2,3-dimercaptosuccininc acid) on succinic dehydrogenase (SDH) activity of fore-, and mid-, and hindbrain and trigeminal ganglia of rats is reported in this study. A dose of 10 mg MMC/kg body weight was injected subcutaneously for 2.7, and 15 days. The chelating agents were also injected subcutaneously in two separate groups of MMC-treated animals except in group 3. In the latter case MMC was injected in two groups of rats for 7 days, and thereafter antagonists were administered daily (40 mg/kg) for 1 week. The result shows inhibition of the enzyme with MMC in all groups and its restoration by N-acetyl-DL-homocysteine thiolactone; 2,3-dimercaptosuccininc acid, however, further reduced the enzyme level. The significance of inhibition of the enzyme in relation to tissue respiration and ATP production is discussed and the capacities of antagonists in the restoration of the SDH level are also analyzed.
- Research Organization:
- Saurashtra Univ., Rajkot, India
- OSTI ID:
- 5714814
- Journal Information:
- Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 43:1; ISSN ENVRA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CHELATING AGENTS
CHLORIDES
CHLORINE COMPOUNDS
ENZYME ACTIVITY
ENZYMES
HALIDES
HALOGEN COMPOUNDS
INJECTION
INTAKE
MAMMALS
MERCURY CHLORIDES
MERCURY COMPOUNDS
MERCURY HALIDES
METHYLMERCURY
NERVE CELLS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
ORGANS
OXIDOREDUCTASES
RATS
RODENTS
SOMATIC CELLS
SUBCUTANEOUS INJECTION
TOXICITY
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CHELATING AGENTS
CHLORIDES
CHLORINE COMPOUNDS
ENZYME ACTIVITY
ENZYMES
HALIDES
HALOGEN COMPOUNDS
INJECTION
INTAKE
MAMMALS
MERCURY CHLORIDES
MERCURY COMPOUNDS
MERCURY HALIDES
METHYLMERCURY
NERVE CELLS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
ORGANS
OXIDOREDUCTASES
RATS
RODENTS
SOMATIC CELLS
SUBCUTANEOUS INJECTION
TOXICITY
VERTEBRATES