Methylmercury chloride-induced and antagonist-reverted succinic dehydrogenase changes in the brain and trigeminal ganglia of the rat
The effect of methylmercury chloride (MMC) toxicity and its antagonism by chelating agents (N-acetyl-DL-homocysteine thiolactone and 2,3-dimercaptosuccininc acid) on succinic dehydrogenase (SDH) activity of fore-, and mid-, and hindbrain and trigeminal ganglia of rats is reported in this study. A dose of 10 mg MMC/kg body weight was injected subcutaneously for 2.7, and 15 days. The chelating agents were also injected subcutaneously in two separate groups of MMC-treated animals except in group 3. In the latter case MMC was injected in two groups of rats for 7 days, and thereafter antagonists were administered daily (40 mg/kg) for 1 week. The result shows inhibition of the enzyme with MMC in all groups and its restoration by N-acetyl-DL-homocysteine thiolactone; 2,3-dimercaptosuccininc acid, however, further reduced the enzyme level. The significance of inhibition of the enzyme in relation to tissue respiration and ATP production is discussed and the capacities of antagonists in the restoration of the SDH level are also analyzed.
- Research Organization:
- Saurashtra Univ., Rajkot, India
- OSTI ID:
- 5714814
- Journal Information:
- Environ. Res.; (United States), Vol. 43:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BRAIN
ENZYME ACTIVITY
CHELATING AGENTS
BIOLOGICAL EFFECTS
METHYLMERCURY
TOXICITY
NERVE CELLS
OXIDOREDUCTASES
MERCURY CHLORIDES
RATS
SUBCUTANEOUS INJECTION
ANIMAL CELLS
ANIMALS
BODY
CENTRAL NERVOUS SYSTEM
CHLORIDES
CHLORINE COMPOUNDS
ENZYMES
HALIDES
HALOGEN COMPOUNDS
INJECTION
INTAKE
MAMMALS
MERCURY COMPOUNDS
MERCURY HALIDES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
ORGANS
RODENTS
SOMATIC CELLS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology