Vitamins and monothiols efficacy in the restoration of adenosine nucleotide degradation enzymes altered during methylmercury intoxication

Journal Article · Sun Dec 31 04:00:00 EST 1995 · Journal of Environmental Pathology, Toxicology and Oncology

OSTI ID:508546

Sood, P P; Bapu, C; Vijayalakshmi, K ^[1]

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1. Saurashtra Univ., Rajkot (India)

Male albino mice were intoxicated with a daily dose of 1 mg/kg of methylmercury chloride (MMC) for 7 days, and were treated thereafter with glutathione, N-acetyl-DL-homocysteine thiolactone, vitamin B complex, and vitamin E, either alone or in combinations for the next 7 days. The animals were sacrificed on the eighth day, with the exception of one group that was kept without toxic exposure for an additional 7 days and sacrificed on the fifteenth day. Brain, spinal cord, kidney, and liver of the animals were examined for changes in adenosine deaminase and 5{prime} nucleotidase. We found a severe inhibition of these enzymes during MMC intoxication and significant recovery during monothiols and vitamins administration, indicating the effectiveness of these agents in methylmercury detoxication. 26 refs., 2 figs.

• OSTI ID: 508546
• Journal Information: Journal of Environmental Pathology, Toxicology and Oncology, Journal Name: Journal of Environmental Pathology, Toxicology and Oncology Journal Issue: 2 Vol. 14; ISSN 0731-8898; ISSN JEPOEC
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
56 BIOLOGY AND MEDICINE
APPLIED STUDIES
ADENOSINE
BIOLOGICAL EFFECTS
DECOMPOSITION
DETOXIFICATION
ENZYME ACTIVITY
ENZYME INHIBITORS
ENZYMES
EVALUATION
GLUTATHIONE
METHYLMERCURY
MICE
NUCLEOTIDES
PERFORMANCE
THERAPY
TOXICITY
VITAMIN B GROUP
VITAMIN E
VITAMINS