Differential therapeutic responses of thiol compounds in the reversal of methylmercury inhibited acid phosphatase and cathepsin E in the central nervous system of rat

Journal Article · Wed Jul 01 04:00:00 EDT 1992 · Bulletin of Environmental Contamination and Toxicology

DOI:https://doi.org/10.1007/BF00193344· OSTI ID:35703

Vinay, S D; Raghu, K G; Sood, P P ^[1]

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1. Saurashtra Univ., Rajkot (India)

Though considerable headway has been made in elucidating the effect of methylmercury on the biochemical machinery of nervous system, the studies on the alterations in the levels of acid hydrolases received less attention. Being a lysosomal marker, acid phosphatase is one of the most extensively studies enzymes amongst the acid hydrolases. Its significance in various key physiological as well as pathological processes is well preserved in literature. Cathepsin E, an aspartic proteinase, has been demonstrated in a number of cells and tissues within the human body, rat, E. coli where its role is implicated in a number of important metabolic processes. In the present paper, we report the results of the differential levels of inhibition of these enzymes with methylmercury as well as their differential recoveries with two thiols (N-acetyl-DL-homocysteine thiolactone and glutathione) in various neuroanatomical areas (olfactory bulbs, cerebral hemispheres, cerebellum, medulla oblongata and spinal cord) of rat. 22 refs., 5 figs.

• Sponsoring Organization: USDOE
• OSTI ID: 35703
• Journal Information: Bulletin of Environmental Contamination and Toxicology, Journal Name: Bulletin of Environmental Contamination and Toxicology Journal Issue: 1 Vol. 49; ISSN 0007-4861; ISSN BECTA6
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
56 BIOLOGY AND MEDICINE
APPLIED STUDIES
ACID PHOSPHATASE
BIOLOGICAL EFFECTS
BIOLOGICAL PATHWAYS
CATHEPSINS
CENTRAL NERVOUS SYSTEM
METHYLMERCURY
MICE
THERAPEUTIC USES
THIOLS