Differential effects of methylmercury, thiols, and vitamins on galactosidases of nervous and non-nervous tissues
Journal Article
·
· Bulletin of Environmental Contamination and Toxicology
- Saurashtra Univ., Rajkot (India)
A rational pharmacological attack on heavy metal poisoning has only been possible with the advent of non-toxic binding of chelating agents. In the recent past, a number of chelators have been used to detoxicate the mercury content from the body. When all the well known chelators were subjected for their therapeutic capacities in the central nervous system, most of the findings were discouraging. In a recent study we have demonstrated the superiority of vitamins over thiol compounds in methylmercury mobilization, which otherwise has been considered difficult and often an impossible task for clinicians as well as toxicologists. Biochemical lesions are considered to be the most primary effects of methylmercury toxication, and lysosomes are the critical cellular organelles which are easily ruptured and release enzymes. In the present study, the biochemical analyses of two lysosomal enzymes (alpha and beta-galactosidases) in various nervous and non-nervous tissues of mice during methylmercury toxication as well as detoxication with vitamins and thiols have been studied in the light of previous investigation related to methylmercury mobilization with these agents. 11 refs., 2 figs.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 35702
- Journal Information:
- Bulletin of Environmental Contamination and Toxicology, Journal Name: Bulletin of Environmental Contamination and Toxicology Journal Issue: 1 Vol. 49; ISSN 0007-4861; ISSN BECTA6
- Country of Publication:
- United States
- Language:
- English
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