Bone extraction and blood clearance of diphosphonate in the dog

Journal Article · Sat Jan 01 04:00:00 EST 1977 · Am. J. Physiol.; (United States)

OSTI ID:6620550

Hughes, S P.F.; Davies, D R; Bassingthwaighte, J B; Knox, F G; Kelly, P J

The transcapillary extraction of diphosphonate, as (/sup 99m/Tc)EHDP, a substance used in bone scanning and for management of certain metabolic bone diseases, has been examined. The maximum instantaneous extraction for (/sup 99m/Tc)EHDP was 0.27 +- 0.05 (mean +- SD,N = 10) and the net extraction at 5 min was 0.18 +- 0.05 (N = 10). The permeability ratio of (/sup 99m/Tc)EHDP to the freely diffusible compound, sucrose, using the formula PS = -F/sub s/ log/sub e/ (1 - E/sub max/), was 0.71. This is similar to the ratio of diffusion coefficients of EHDP to sucrose, which is estimated to be 0.78. These results suggest that the mechanism by which (/sup 99m/Tc)EHDP passes through the capillaries in bone is passive diffusion. Tissue level estimations of EHDP confirm a rapid blood clearance associated with an increase in the rate of urinary excretion; the level of (/sup 99m/Tc)EHDP in bone, however, remains constant. The fractional excretion of (/sup 99m/Tc)EHDP was 27.3 +- 2.0% in control dogs and was unchanged by thyroparathyroidectomy and subsequent infusion of parathyroid hormone.

• Research Organization: Mayo Clinic, Rochester, MN
• OSTI ID: 6620550
• Journal Information: Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States) Vol. 1:1; ISSN AJPHA
• Country of Publication: United States
• Language: English

Related Subjects

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59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD VESSELS
BODY
BODY FLUIDS
BONE TISSUES
CAPILLARIES
CARDIOVASCULAR SYSTEM
CLEARANCE
CONNECTIVE TISSUE
DIFFUSION
DISEASES
DOGS
EXCRETION
LABELLED COMPOUNDS
MAMMALS
OXYGEN COMPOUNDS
PHOSPHATES
PHOSPHORUS COMPOUNDS
SKELETAL DISEASES
TISSUES
VERTEBRATES