Optimization of the ratio of stannous tin: ethane-1-hydroxy-1, 1- diphosphonate for bone scanning with /sup 99m/Tc-pertechnetate

Journal Article · Fri Feb 01 04:00:00 EDT 1974 · J. Nucl. Med., v. 15, no. 2, pp. 69-74

OSTI ID:4327688

Tofe, A J; Francis, M D

BS>Using synthetic hydroxyapatite (HA) as an in vitro skeletal model, the optimum formulation of a /sup 99m/Tc-distannous ethane1-hydroxy-1, 1- diphosphonate (/sup 99m/Tc --Sn - EHDP) bone scanning agent was determined by measurement of the amount of radiotagged components (/sup 99m/Tc, /sup 113/Sn, and 1-/sup 14/C --EHDP) on HA. A range of EHDP to stannous chloride weight ratios (5: 1 to 50: 1) was found to yield complete (>95%) sorption on HA of the / sup 99m/Tc-Sn -EHDP bone scanning agent. Using the 12: 1 and 50: 1 ratios, organ distribution and blood clearance for 1-/sup 14/C--EHDP, /sup 113/Sn, and /sup 99m/ Tc were determined in Sprague --Dawley rats. Major whole organs, selected skeletal samples, urine, and feces were assayed by liquid scintillation and gamma spectrometers. The /sup 99m/Tc--Sn EHDP agent was found to be nearly evenly distributed between the skeleton and urine with less than 2% of the dose in soft tissue. The /sup 99m/Tc --Sn - EHDP agent yielded excellent scintiscans of the skeletal system. The rapid blood clearance is comparable to /sup 18/F, and the physical and chemical properties of the diphosphonate agent suggest an advantage over the /sup 99m/Tc-labeled polyphosphate or pyrophosphate bone scanning agents. (auth)

• Research Organization: Procter and Gamble Co., Cincinnati
• NSA Number: NSA-29-021289
• OSTI ID: 4327688
• Journal Information: J. Nucl. Med., v. 15, no. 2, pp. 69-74, Journal Name: J. Nucl. Med., v. 15, no. 2, pp. 69-74; ISSN JNMEA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

*BONE TISSUES-- SCINTISCANNING
APATITES
BIOLOGICAL MATERIALS
CARBON 14
COMPARATIVE EVALUATIONS
DIAGNOSTIC TECHNIQUES
HYDROXY COMPOUNDS
ISOMERIC NUCLEI
LABELLED COMPOUNDS
MOCKUP
N48830* --Life Sciences--New Tracer Techniques--Other
NUCLEAR MEDICINE
PHOSPHATES
RADIONUCLIDE ADMINISTRATION
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
RATS
TECHNETIUM 99
TESTING
TIN 113
TISSUE DISTRIBUTION
TRACER TECHNIQUES
UPTAKE TISSUE DISTRIBUTION