Skeletal uptake /sup 99m/Tc-diphosphonate in relation to local bone blood flow. [Rats]
The right/left ratios of tibial uptake of /sup 99m/Tc-diphosphonate (EHDP) and relative blood flow (based on microsphere distribution) were determined in control rats and rats with a ligated right femoral artery or a healing right tibial fracture. Correlation between /sup 99m/Tc-EHDP uptake and relative blood flow was highly significant (r = 0.917; P less than 0.0001) for relative flow ratios less than 1.7. When the ratio was greater than 1.7, there was little further increase in /sup 99m/Tc-EHDP uptake. Ligation of the femoral artery in rats with healing fractures resulted in a more marked reduction of blood flow than of /sup 99m/Tc-EHDP uptake. These results suggest that regional bone blood flow is a major determinant of /sup 99m/Tc-EHDP uptake, though changes in regional tracer extraction efficiency are also important.
- Research Organization:
- Armed Forces Radiobiology Research Inst., Bethesda, MD
- OSTI ID:
- 7348992
- Journal Information:
- Radiology; (United States), Journal Name: Radiology; (United States) Vol. 120:1; ISSN RADLA
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ARTERIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BLOOD FLOW
BLOOD VESSELS
BODY
BONE FRACTURES
BONE TISSUES
CARDIOVASCULAR SYSTEM
CONNECTIVE TISSUE
DISEASES
HOURS LIVING RADIOISOTOPES
INJURIES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
PHOSPHONATES
RADIOISOTOPES
RADIONUCLIDE KINETICS
RATS
RODENTS
SKELETAL DISEASES
TECHNETIUM 99
TECHNETIUM ISOTOPES
TISSUES
UPTAKE
VERTEBRATES
YEARS LIVING RADIOISOTOPES