Localization of a highly conserved human potassium channel gene (NGK2-KV4-KCNC1) to chromosome 11p15

Journal Article · Mon Feb 01 04:00:00 EST 1993 · Genomics; (United States)

DOI:https://doi.org/10.1006/geno.1993.1075· OSTI ID:6619600

Ried, T; Ward, D C ^[1]; Rudy, B; Miera, V.S. de; Lau, D; Sen, K ^[2]

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1. Yale Univ. School of Medicine, New Haven, CT (United States)
2. New York Univ. Medical Center, New York (United States)

Several genes (the Shaker or Sh gene family) encoding components of voltage-gated K[sub +] channels have been identified in various species. Based on sequence similarities Sh genes are classified into four groups or subfamilies. Mammalian genes of each one of these subfamilies also show high levels of sequence similarity to one of four related Drosophila genes: Shaker, Shab, Shaw, and Shal. Here we report the isolation of human cDNAs for a Shaw-related product (NGK2,KV2.1a) previously identified in rat and mice. A comparison of the nucleotide and deduced amino acid sequence of NGK2 in rodents and humans shows that this product is highly conserved in mammals; the human NGK2 protein shows over 99% amino acid sequence identity to its rodent homologue. The gene (NGK2-KV4; KCNC1) encoding NGK2 was mapped to human chromosome 11p15 by fluorescence in situ hybridization with the human NGK2 cDNAs. 65 refs., 2 figs., 1 tab.

• OSTI ID: 6619600
• Journal Information: Genomics; (United States), Journal Name: Genomics; (United States) Vol. 15:2; ISSN GNMCEP; ISSN 0888-7543
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
ALKALI METALS
AMINO ACID SEQUENCE
ANIMALS
ARTHROPODS
CHROMOSOMES
DIPTERA
DNA SEQUENCING
DROSOPHILA
ELEMENTS
FLIES
FLUORESCENCE
FRUIT FLIES
GENES
GENETIC MAPPING
HUMAN CHROMOSOMES
HYBRIDIZATION
INSECTS
INVERTEBRATES
LUMINESCENCE
MAMMALS
MAPPING
MEMBRANE PROTEINS
METALS
MICE
MOLECULAR STRUCTURE
ORGANIC COMPOUNDS
POTASSIUM
PROTEINS
RODENTS
STRUCTURAL CHEMICAL ANALYSIS
VERTEBRATES