Assignment of human potassium channel gene KCNA4 (Kv1. 4, PCN2) to chromosome 11q13. 4 [r arrow] q14. 1

Journal Article · Mon Feb 01 04:00:00 EST 1993 · Genomics; (United States)

DOI:https://doi.org/10.1006/geno.1993.1094· OSTI ID:6619467

Philipson, L H; Bell, G I ^[1]; Eddy, R L; Shows, T B ^[2]

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1. Univ. of Chicago, IL (United States)
2. Roswell Park Cancer Inst., Buffalo, NY (United States)

Both electrically excitable and nonexcitable tissues express voltage-sensitive K[sup +] channels. Since the original isolation of the Drosophila Shaker gene encoding voltage-sensitive K[sub +] channels, five additional related gene families have been described: the Shal, Shab, and Shaw families and the K-eag and Slo genes. A seventh family of slowly activating K[sup +] channels, minK of IsK, is structurally unrelated to the others. Seven human genes related to the Shaker subfamily have been described. We recently described the cloning of a fast-inactivating human voltage-gated K[sup +] channel, PCN2. Here we report the mapping of the gene encoding PNC2, designated KNCA4, to chromosome 11 by analyzing its segregation in a panel of reduced human-mouse somatic cell hybrids. In situ hybridization to prometaphase chromoxomes localized KCNA4 to the long arm of chromosome 11 in the region of bands q13.4 [r arrow] q14.1.

• OSTI ID: 6619467
• Journal Information: Genomics; (United States), Journal Name: Genomics; (United States) Vol. 15:2; ISSN GNMCEP; ISSN 0888-7543
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
ALKALI METALS
ANIMALS
ARTHROPODS
BODY
CHROMOSOMES
CLONING
DIPTERA
DROSOPHILA
ELEMENTS
FLIES
FRUIT FLIES
GENES
GENETIC MAPPING
HUMAN CHROMOSOMES
HYBRIDIZATION
INSECTS
INVERTEBRATES
MAPPING
MEMBRANE PROTEINS
MEMBRANE TRANSPORT
METALS
ORGANIC COMPOUNDS
POTASSIUM
PROTEINS
SEGREGATION
TISSUES