In vivo and in vitro alteration of nicotine metabolism by the major metabolite of phenytoin
Journal Article
·
· Res. Commun. Chem. Pathol. Pharmacol.; (United States)
OSTI ID:6619489
The influence of hydroxyphenytoin (HPPH), the major metabolite of phenytoin, on the in vitro and in vivo metabolism of nicotine was examined. In rat liver 9,000 g supernatant HPPH decreased the appearance of cotinine from nicotine by 65% while not influencing the disappearance of nicotine or the appearance of nicotine-1'-N-oxide. In vivo, HPPH inhibited both nicotine elimination and cotinine formation but did not affect nicotine-1'-N-oxide formation.
- Research Organization:
- Univ. of Kentucky, Lexington
- OSTI ID:
- 6619489
- Journal Information:
- Res. Commun. Chem. Pathol. Pharmacol.; (United States), Journal Name: Res. Commun. Chem. Pathol. Pharmacol.; (United States) Vol. 19:2; ISSN RCOCB
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALOIDS
AMINES
ANIMALS
AZINES
AZOLES
BIOLOGICAL EFFECTS
BODY
CLEARANCE
DIGESTIVE SYSTEM
GLANDS
HETEROCYCLIC COMPOUNDS
IN VITRO
IN VIVO
INHIBITION
LIVER
MAMMALS
METABOLISM
METABOLITES
NICOTINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRIDINES
PYRROLES
PYRROLIDINES
RATS
RESPONSE MODIFYING FACTORS
RODENTS
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALOIDS
AMINES
ANIMALS
AZINES
AZOLES
BIOLOGICAL EFFECTS
BODY
CLEARANCE
DIGESTIVE SYSTEM
GLANDS
HETEROCYCLIC COMPOUNDS
IN VITRO
IN VIVO
INHIBITION
LIVER
MAMMALS
METABOLISM
METABOLITES
NICOTINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRIDINES
PYRROLES
PYRROLIDINES
RATS
RESPONSE MODIFYING FACTORS
RODENTS
VERTEBRATES