In vivo distribution of carbon-11 phenytoin and its major metabolite, and their use in scintigraphic imaging. [Rhesus monkeys]

Journal Article · Tue Aug 01 04:00:00 EDT 1978 · J. Nucl. Med.; (United States)

OSTI ID:6555391

Stavchansky, S A; Tilbury, R S; McDonald, J M; Ting, C T; Kostenbauder, H B

Curie quantities (0.3 to 1.5 Ci) of H/sup 11/CN were used in the synthesis of C-11-tagged phenytoin (C-11.DPH) and 5-(p-hydroxyphenyl)-5-phenylhydantoin (C-11.HPPH), using a modified Buecherer--Bergs reaction. The H/sup 11/CN was produced from a mixture of 95% nitrogen and 5% hydrogen by a 45-min bombardment with 10-MeV protons at 10 ..mu..A. Following iv infusions of C-11 DPH (13.7 mg/kg at a rate of 29 mg/min) into the left femoral vein of Rhesus monkeys, DPH shows persistent concentration in the brain and liver fields. Extravascular administration shows significant retention at the site of administration. Intravenous bolus injection of (/sup 11/C)-HPPH into a Rhesus monkey, at a dose of 6.4 mg/kg, resulted in localization of this compound in the liver, gallbladder, urinary bladder, and intestinal fields. Loss of activity from the liver region, with appearance of this activity in the intestinal field, suggests that (/sup 11/C)-HPPH is secreted into the intestine via the bile. Further investigation is needed to study the potential of (/sup 11/C)-DPH as a brain-scanning agent and (/sup 11/C)-HPPH as a possible cholescintigraphic agent.

• Research Organization: Univ. of Texas, Austin
• OSTI ID: 6555391
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 19:8; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702* -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BILIARY TRACT
BIOLOGICAL LOCALIZATION
BLADDER
BODY
BRAIN
CARBON 11
CARBON ISOTOPES
CENTRAL NERVOUS SYSTEM
CHEMICAL PREPARATION
CHEMISTRY
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DRUGS
EVEN-ODD NUCLEI
GASTROINTESTINAL TRACT
GLANDS
INJECTION
INTAKE
INTESTINES
INTRAVENOUS INJECTION
ISOTOPES
LABELLED COMPOUNDS
LABELLING
LIGHT NUCLEI
LIVER
MACACUS
MAMMALS
METABOLITES
MINUTES LIVING RADIOISOTOPES
MONKEYS
NERVOUS SYSTEM
NUCLEI
ORGANS
PRIMATES
RADIOACTIVE MATERIALS
RADIOCHEMISTRY
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
SCINTISCANNING
SYNTHESIS
URINARY TRACT
VERTEBRATES