THE EFFECT OF IONIZING RADIATION ON ACETYLCHOLINE METABOLISM IN MACACA- RHESUS MONKEYS

Journal Article · Wed Nov 01 04:00:00 EST 1961 · Biochemistry (U.S.S.R.) (English Translation)

OSTI ID:4828766

Demin, N N; Korneeva, N V; Shaternikov, V A

In macaca-rhesus monkeys the normal content of free acetylcholine in the mucosa of the small intestine was higher, as it was in brain and liver, than bound acetyl choline. The total cholinesterase activity and, particularly, the activity of acetylcholinesterase and non-specific cholinesterase in control monkeys is highest in brain, followed by intestinal mucosa and liver. One to three days after gamma -irradiation of the monkey at a dose of 600 r the amount of free and bound acetylcholine in the mucosa of the small intestine increased, while it decreased in liver. The total cholinesterase activity in the mucosa of the small intestine during this period increased, in general because of the increase in the activity of non-specific cholinesterase. In the liver the increase in total cholinesterase activity also occurred because of an increase in non-specific cholinesterase activity, but was less clear-cut and occurred later (the third day after irradiation). In animals irradiated 2 to 3 years before the investigation, an increased concentration of free acetylcholine in brain, liver, and mucosa of the small intestine was noted; but there were no ehanges in bound acetylcholine. The total cholinesterase activity increased in liver as a result of acetyl cholinesterase increase and non-specific enzymes, and in mucosa of the small intestine only as a result of acetylcholinesterase activity. In brain the total cholinesterase activity decreased as a consequence of a decrease in acetylcholinesterase activity. (auth)

• Research Organization: Inst. of Experimental Pathology and Therapy, Academy of Sciences, Sukhumi, USSR
• NSA Number: NSA-16-004042
• OSTI ID: 4828766
• Journal Information: Biochemistry (U.S.S.R.) (English Translation), Journal Name: Biochemistry (U.S.S.R.) (English Translation) Vol. Vol: 26
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ACETIC ACID
ACETYL RADICALS
ACETYLCHOLINE
BIOLOGY AND MEDICINE
BRAIN
CHOLINE
ENZYMES
GAMMA RADIATION
INTESTINE
LIPIDS
LIVER
MONKEYS
RADIATION DOSES
RADIATION EFFECTS
VITAMIN B GROUP
VITAMINS