Effects of feeding selenium deficient diets to rhesus monkeys (Macaca Mulatta)

Journal Article · Mon Feb 01 04:00:00 EST 1988 · J. Am. Coll. Nutr.; (United States)

DOI:https://doi.org/10.1080/07315724.1988.10720219· OSTI ID:5284636

Butler, J A; Whanger, P D; Patton, N M

Pregnant rhesus monkeys (Macaca mulatta) were fed either selenium (Se) deficient or Se supplemented diets with adequate vitamin E. Except for some cardiac irregularities in the first babies born to these females, no physiological disorders due to Se deficiency were seen in a subsequent offspring. Plasma and erythrocyte glutathione peroxidase activities and blood Se levels increased in the Se supplemented monkeys but decreased in the deficient ones. The data indicated that hair Se levels reflect long term exposure to this element. In a very preliminary experiment, evidence was obtained to indicate that dietary protein deficiency along with Se deficiency will generate cardiomyopathic lesions characteristic of Se deficiency. It is hypothesized that, in addition to Se deficiency, another dietary deficiency (or abnormality) is necessary to produce Se deficiency lesions in higher primates. Higher glutathione transferase (or non-Se glutathione peroxidase) activity in tissues of rhesus monkeys may account for this resistance.

• Research Organization: Oregon State Univ., Corvallis (USA)
• OSTI ID: 5284636
• Journal Information: J. Am. Coll. Nutr.; (United States), Journal Name: J. Am. Coll. Nutr.; (United States) Vol. 7:1; ISSN JONUD
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
DIGESTIVE SYSTEM
ELEMENTS
ENZYME ACTIVITY
ENZYMES
ERYTHROCYTES
FOOD
GLANDS
HAIR
LIVER
MAMMALS
MATERIALS
MILK
MONKEYS
NUTRITIONAL DEFICIENCY
ORGANS
OXIDOREDUCTASES
PEROXIDASES
PREGNANCY
PRIMATES
SELENIUM
SEMIMETALS
SKIN
TOXICITY
VERTEBRATES
VITAMIN E
VITAMINS