Modulation of pulmonary defense mechanisms by acute exposures to nitrogen dioxide. [Staphylococcus aureus; Proteus mirabilis; Pasteurella pneumotropica]

Journal Article · Sun Feb 01 04:00:00 EST 1987 · Environ. Res.; (United States)

OSTI ID:6609826

Jakab, G J

The effect of acute exposures to NO/sub 2/ on the antibacterial defenses of the murine lung was assessed following inhalation challenges with Staphylococcus aureus, Proteus mirabilis, and Pasteurella pneumotropica. With S. aureus pulmonary antibacterial defenses were suppressed at NO/sub 2/ levels of 4.0 ppm and greater. Exposure to 10.0 ppm enhanced the intrapulmonary killing of P. mirabilis which correlated with an increase in the phagocytic cell populations lavaged from the lungs; at 20.0 ppm bactericidal activity against P. mirabilis was impaired. Pulmonary antibacterial defenses against P. pneumotropica were impaired at 10.0 ppm which correlated with a decrease in the retrieved phagocytic lung cell population. Reversing the order of treatment (ie., NO/sub 2/ exposure prior to bacterial challenge) raised the threshold concentration for NO/sub 2/-induced impairment of intrapulmonary bacterial killing. With S. aureus the effect was not observed at 5.0 ppm but at 10.0 ppm and with P. mirabilis not at 20.0 ppm but at 30.0 ppm intrapulmonary killing was enhanced. Exposures up to 20.0 ppm of NO/sub 2/ did not effect the physical translocation mechanisms of the lung as quantitated by declines in pulmonary radiotracer activity following aerogenic challenge with /sup 32/P-labeled staphylococci.

• Research Organization: Johns Hopkins Univ. of School of Hygiene and Public Health, Baltimore, MD
• OSTI ID: 6609826
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 42:1; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

551001 -- Physiological Systems-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BACTERIA
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CHALCOGENIDES
DAYS LIVING RADIOISOTOPES
DOSES
IMMUNITY
IMMUNOSUPPRESSION
INFECTIVITY
INHALATION
INTAKE
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
LUNGS
MAMMALS
MICE
MICROORGANISMS
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
NUCLEI
ODD-ODD NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
PHAGOCYTOSIS
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
RADIATION DOSES
RADIOISOTOPES
RESPIRATORY SYSTEM
RODENTS
THRESHOLD DOSE
TOXICITY
TRACER TECHNIQUES
VERTEBRATES