Effect of hydrogen sulfide on bacterial inactivation in the rat lung

Journal Article · Tue Sep 01 04:00:00 EDT 1981 · Arch. Environ. Health; (United States)

DOI:https://doi.org/10.1080/00039896.1981.10667634· OSTI ID:5868913

Rogers, R E; Ferin, J

This study evaluated the effect of a low concentration of hydrogen sulfide on the rat antibacterial defense system. Rats exposed to 45 ppm hydrogen sulfide (threshold limit value for hydrogen sulfide = 10 ppm) for 4 or 6 hr exhibited a significant (p < .01) reduction in the inactivation of viable staphylococci deposited in the lungs during a bacterial aerosol challenge. Pre-exposure of rats to 46 ppm hydrogen sulfide for 2 hr, however, did not alter intrapulmonary staphylococcal inactivation. We hypothesize that impairment of the alveolar macrophage is the basis of these findings.

• Research Organization: Univ. of Rochester, NY
• DOE Contract Number: EY-76-C-02-3490
• OSTI ID: 5868913
• Journal Information: Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 36:5; ISSN AEHLA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism &amp; Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
ANTIBODY FORMATION
BACTERIA
BIOLOGICAL EFFECTS
BODY
CHALCOGENIDES
COLLOIDS
DISPERSIONS
HYDROGEN COMPOUNDS
HYDROGEN SULFIDES
INACTIVATION
LUNGS
MAMMALS
MICROORGANISMS
ORGANS
RATS
RESPIRATORY SYSTEM
RODENTS
SOLS
STAPHYLOCOCCUS
SULFIDES
SULFUR COMPOUNDS
VERTEBRATES