Cell cycle-dependent potentiation of X-ray-induced chromosomal aberrations by 3-aminobenzamide
Journal Article
·
· Biochem. Biophys. Res. Commun.; (United States)
The poly(ADP-ribose) polymerase inhibitor 3-aminobenzamide had dramatically different effects on X-ray-induced cytogenetic damage in human lymphocytes depending on the stage of the cell cycle in which cells were irradiated. 3-Aminobenzamide (0.08-3.00 mM) potentiated the frequency of chromosomal aberrations when lymphocytes were irradiated in G1, S, or late G2. No effect was observed, however, when lymphocytes were irradiated in G0 or at the S/G2 boundary 6 h before termination of culture. These results indicate that poly(ADP-ribose) polymerase may be involved in chromosomal repair of radiation damage only during specific stages of the cell cycle.
- Research Organization:
- Univ. of California, San Francisco
- OSTI ID:
- 6589084
- Journal Information:
- Biochem. Biophys. Res. Commun.; (United States), Journal Name: Biochem. Biophys. Res. Commun.; (United States) Vol. 1; ISSN BBRCA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Cytological and molecular studies of chromosomal radiosensitivity in Down Syndrome cells
DNA repair and chromosome aberrations: the effect of cytosine arabinoside on the frequency of chromosome aberrations induced by radiation and chemicals
Synergistic effect of aphidicolin on the yield of X-ray-induced chromosome aberrations throughout the cell cycle in JU56 cells
Thesis/Dissertation
·
Thu Dec 31 23:00:00 EST 1987
·
OSTI ID:5259583
DNA repair and chromosome aberrations: the effect of cytosine arabinoside on the frequency of chromosome aberrations induced by radiation and chemicals
Journal Article
·
Mon Dec 31 23:00:00 EST 1979
· Teratog., Carcinog., Mutagen.; (United States)
·
OSTI ID:5403971
Synergistic effect of aphidicolin on the yield of X-ray-induced chromosome aberrations throughout the cell cycle in JU56 cells
Journal Article
·
Mon Jun 01 00:00:00 EDT 1987
· Radiat. Res.; (United States)
·
OSTI ID:6471977
Related Subjects
560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL CYCLE
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
ENZYME INHIBITORS
ENZYMES
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
IONIZING RADIATIONS
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MAN
MATERIALS
MUTATIONS
NUCLEOTIDYLTRANSFERASES
PHOSPHORUS-GROUP TRANSFERASES
POLYMERASES
PRIMATES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
SOMATIC CELLS
TRANSFERASES
VERTEBRATES
X RADIATION
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL CYCLE
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
ENZYME INHIBITORS
ENZYMES
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
IONIZING RADIATIONS
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MAN
MATERIALS
MUTATIONS
NUCLEOTIDYLTRANSFERASES
PHOSPHORUS-GROUP TRANSFERASES
POLYMERASES
PRIMATES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
SOMATIC CELLS
TRANSFERASES
VERTEBRATES
X RADIATION