Early in vivo detection of acute canine myocardial ischemia by NMR

Conference · Sun Jan 01 04:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:6587689

Pflugfelder, P W; Wisenberg, G; Prato, F S; Carroll, S E; Turner, K L

To determine the ability of proton nuclear magnetic resonance imaging (NMRI) to detect early myocardial ischemic injury, a ligature was placed around the anterior descending (3) or circumflex(3) artery in 6 dogs. In vivo imaging was done at end diastole using a .15T (6.25MHz) resistive NMR unit prior to and for 4-6 hours after coronary artery occlusion. Image acquisition was by spin echo (SE) (TE 30 msec TR<1sec, TE 30 msec TR>1sec, TE 60 msec TR>1sec) and inversion recovery (IR) pulse sequences. Compared to normal surrounding myocardium, NMR signal increased within the ischemic zone. Changes of evolving infarction by microscopic examination of the excised heart correlated well with the extent of NMR changes. Excellent visualization of the ischemic zone was obtained using the SE technique, particularly the TE 60 msec SE sequence. IR imaging did not demonstrate ischemia. T2 of ischemic myocardium was increased 50 +- 3% above normal myocardium in the first hour and 78 +- 27% in the third hour post occlusion (p<.05). The authors conclude that NMRI can detect early myocardial ischemic injury, best with the TE 60 msec SE sequence, thus providing a potential tool for evaluating the efficacy of interventions to limit myocardial infarct size.

• Research Organization: St. Joseph's Hospital, London
• OSTI ID: 6587689
• Report Number(s): CONF-840619-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 25:5
• Country of Publication: United States
• Language: English

Related Subjects

550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BARYONS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
DETECTION
DIAGNOSTIC TECHNIQUES
DISEASES
DOGS
ELEMENTARY PARTICLES
ELEMENTS
EVALUATION
FERMIONS
HADRONS
HEART
HYDROGEN
IMAGE PROCESSING
IN VIVO
ISCHEMIA
MAMMALS
MORPHOLOGY
MUSCLES
MYOCARDIAL INFARCTION
MYOCARDIUM
NMR IMAGING
NONMETALS
NUCLEONS
ORGANS
PROCESSING
PROTONS
SIGNALS
VASCULAR DISEASES
VERTEBRATES