Proton NMR imaging in experimental ischemic infarction
Proton nuclear magnetic resonance (NMR) images depict the distribution and concentration of mobile protons modified by the relaxation times T1 and T2. Using the steady-state-free-precession (SSFP) technique, serial coronal images were obtained sequentially over time in laboratory animals with experimental ischemic infarction. Image changes were evident as early as 2 hours after carotid artery ligation, and corresponded to areas of ischemic infarction noted pathologically. Resulting SSFP images in experimental stroke are contrasted to inversion-recovery NMR images in an illustrative patient with established cerebral infarction. Bulk T1 and T2 measurements were made in vitro in three groups of gerbils: normal, those with clinical evidence of infarction, and those clinically normal after carotid ligature. Infarcted hemispheres had significantly prolonged T1 and T2 (1.47 +/- .12 sec, 76.0 +/- 9.0 msec, respectively) when compared to the contralateral hemisphere (T1 . 1.28 +/- .05 sec, T2 . 58.7 +/- 3.9 msec) or to the other two groups. These data suggest that changes in NMR parameters occur and can be detected by NMR imaging as early as two hours after carotid artery ligation.
- Research Organization:
- Department of Neurology, Radiology, Surgery and Medicine, Massachusetts General Hospital, Boston
- OSTI ID:
- 5854623
- Journal Information:
- Stroke; (United States), Vol. 14:2
- Country of Publication:
- United States
- Language:
- English
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BRAIN
NUCLEAR MAGNETIC RESONANCE
ISCHEMIA
DIAGNOSTIC TECHNIQUES
VASCULAR DISEASES
BIOLOGICAL MODELS
BLOOD CIRCULATION
GERBILS
IMAGES
ANIMALS
BODY
CARDIOVASCULAR DISEASES
CENTRAL NERVOUS SYSTEM
DISEASES
MAGNETIC RESONANCE
MAMMALS
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ORGANS
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VERTEBRATES
550602* - Medicine- External Radiation in Diagnostics- (1980-)