Comparison of I-123 IMP cerebral uptake and MR spectroscopy following experimental carotid occlusion

Journal Article · Mon Jul 01 00:00:00 EDT 1985 · Invest. Radiol.; (United States)

DOI:https://doi.org/10.1097/00004424-198507000-00006· OSTI ID:6300357

Holman, B L; Jolesz, F A; Polak, J F; Kronauge, J F; Adams, D F

Both I-123 IMP scintigraphy and MRI have been suggested as sensitive detectors of changes shortly after acute cerebral infarction. We compared the uptake of N-isopropyl I-123 p-iodoamphetamine (IMP) and MR spectroscopy of the brain after internal carotid artery ligation. Thirteen gerbils were lightly anesthetized with ether. After neck dissection, an internal carotid artery was occluded. After 2.8 hours, 100 muCi I-123 IMP was injected intravenously into the 13 experimental animals plus three controls. Seven gerbils remained asymptomatic while six developed hemiparesis. At 3 hours after ligation, the animals were killed. The brains were bisected and T1 and T2 relaxation times were determined for the right and left hemispheres by MR spectroscopy immediately after dissection. I-123 IMP uptake was then determined in the samples. Interhemispheric differences in uptake for I-123 IMP were 0.1 +/- 1.7% (SEM) in the control, 33.5 +/- 10% in the asymptomatic and 54.6 +/- 9.7% in the symptomatic animals. Significant differences were seen with I-123 IMP in 6/7 asymptomatic and 6/6 symptomatic animals. In conclusion, I-123 is more sensitive than T1 or T2 relaxation times for the detection of cerebral perfusion abnormalities. Prolongation in T1 and T2 relaxation times correlates closely with increased brain tissue water content and the development of symptoms, indicators of structural brain damage and probable infarction.

• Research Organization: Harvard Medical School, Boston, MA
• OSTI ID: 6300357
• Journal Information: Invest. Radiol.; (United States), Vol. 4
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BRAIN
SCINTISCANNING
IODINE 123
UPTAKE
VASCULAR DISEASES
DIAGNOSIS
AMPHETAMINES
COMPARATIVE EVALUATIONS
GERBILS
NUCLEAR MAGNETIC RESONANCE
PERFUSED ORGANS
ANALEPTICS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BODY
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MAGNETIC RESONANCE
MAMMALS
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESONANCE
RODENTS
SYMPATHOMIMETICS
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics