Comparison of I-123 IMP uptake and NMR spectroscopy in the brain following experimental carotid occlusion

Conference · Sun Jan 01 04:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:6546956

Holman, B L; Jolesz, F; Polak, J F; Kronauge, J; Adams, D F

Both I-123 IMP scintigraphy and NMR have been suggested as sensitive detectors of changes shortly after acute cerebral infarction. The authors compared the uptake of N-isopropul I-123 p-iodoamphetamine (IMP) and NMR spectroscopy of the brain after internal carotid artery ligation. Thirteen gerbils were lightly anesthetized with ether. After neck dissection, an internal carotid artery was occluded. After 2.8 hours, 100 ..mu..Ci I-123 IMP was injected intravenously into the 13 experimental animals plus 3 controls. Seven gerbils remained asymptomatic while 6 developed hemiparesis. At 3 hours after ligation, the animals were killed. The brains were bisected and T/sub 1/ and T/sub 2/ relaxation times were determined for the right and left hemispheres by NMR spectroscopy immediately after dissection. I-123 IMP uptake was then determined in the samples. Interhemispheric differences in uptake for I-123 IMP uptake was 2.2% +- 0.5% in the control, 33.5% +- 9.6% in the asymptomatic and 54.6% +- 9.7% in the symptomatic animals. Significant differences were seen with I-123 IMP in 6/7 asymptomatic and 6/6 symptomatic animals. Significant differences in T/sub 1/ and T/sub 2/ were seen in 2/7 of the asymptomatic and 5/6 of the symptomatic animals. The authors conclude that I-123 is more sensitive than T/sub 1/ or T/sub 2/ for the detection of cerebral perfusion abnormalities while T/sub 1/ and T/sub 2/ more accurately separate symptomatic from asymptomatic animals.

• Research Organization: Harvard Medical School, Boston, MA
• OSTI ID: 6546956
• Report Number(s): CONF-840619-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 25:5
• Country of Publication: United States
• Language: English

Related Subjects

550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
AMPHETAMINES
ANALEPTICS
ANIMALS
ARTERIES
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BLOOD VESSELS
BODY
BRAIN
CARDIOVASCULAR SYSTEM
CAROTID ARTERIES
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
GERBILS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAGNETIC RESONANCE
MAMMALS
MORPHOLOGICAL CHANGES
MORPHOLOGY
NERVOUS SYSTEM
NMR IMAGING
NUCLEAR MAGNETIC RESONANCE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATHOLOGICAL CHANGES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
RELAXATION TIME
RESONANCE
RODENTS
SCINTISCANNING
SYMPATHOMIMETICS
UPTAKE
VERTEBRATES