Comparison of two cerebral perfusion tracers, N-isopropyl I-123 p-iodoamphetamine and I-123 HIPDM, in the human
Both N-isopropyl I-123 p-iodoamphetamine (IMP) and I-123 HIPDM have been advocated as radiotracers for assessing regional cerebral perfusion. We compared the biodistribution of the two tracers in 19 patients without evidence of neurological disease. Following intravenous injection, both tracers accumulated initially in the lung. Early after injection the fraction of the total brain uptake was higher for I-123 HIPDM than for I-123 IMP. The peak brain activity for I-123 IMP was higher than for I-123 HIPDM. Brain activity was unchanged with both tracers between 30 and 60 min after injection. Tomographic images were similar in appearance for both tracers. No eye uptake greater than background was observed with either tracer in any patient at 2, 24, and 48 hr. I-123 IMP is superior for tomographic imaging because of its higher brain uptake, whereas I-123 HIPDM may be superior for studies performed during rapid changes in blood flow.
- Research Organization:
- Harvard Medical School, Boston, MA
- OSTI ID:
- 5433020
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 25:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
CEREBRUM
RADIOISOTOPE SCANNING
TOMOGRAPHY
IODINE 123
RADIOPHARMACEUTICALS
COMPARATIVE EVALUATIONS
TISSUE DISTRIBUTION
AMINES
LUNGS
PATIENTS
PERFUSED TISSUES
ANIMAL TISSUES
BETA DECAY RADIOISOTOPES
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RESPIRATORY SYSTEM
TISSUES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
400702 - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials