Quantitative cerebral blood flow measurements using N-isopropyl-(iodine 123) p-iodoamphetamine and single photon emission computed tomography with rotating gamma camera
Sixty regional cerebral blood flow measurements were performed on 4 normal volunteers, 7 epileptics, and 40 cerebrovascular disorders using intravenously injected N-isopropyl-(I-123)p-iodoamphetamine (123I-IMP) and single photon emission computed tomography with rotating gamma camera. Arterial blood sampling was combined for obtaining absolute blood flow values. The brain activity distributions of the tomographic image from 30 min after injection, when brain activity reached a plateau, were corrected to represent 5-min reference values with the use of the monitored entire brain's time-activity curve. Brain mean blood flow values ranged from 54 to 63, 34 to 59, and 20 to 60 ml/100 g/min, in normal volunteers, epileptics, and subjects with cerebrovascular disorders, respectively. Brain mean /sup 123/I-IMP uptake corrected for injection dose did not correlate with these absolute flow values. This quantitative method is especially useful for diagnosing diffuse flow reductions, which were observed in 8 (14%) of 56 studies in the patients.
- Research Organization:
- Kanazawa Univ., Ishikawa (Japan)
- OSTI ID:
- 6908602
- Journal Information:
- Am. J. Physiol. Imag.; (United States), Journal Name: Am. J. Physiol. Imag.; (United States) Vol. 1:4; ISSN AJPIE
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
AMPHETAMINES
ANALEPTICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BLOOD FLOW
BODY
BRAIN
CAMERAS
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
EPILEPSY
GAMMA CAMERAS
HOURS LIVING RADIOISOTOPES
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTRAVENOUS INJECTION
IODINE 123
IODINE ISOTOPES
ISOTOPES
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
SCINTILLATION COUNTING
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
SYMPATHOMIMETICS
TOMOGRAPHY
VASCULAR DISEASES